Mechanosensing can result from adhesion molecule dynamics.

Biophysical Journal
Paulina Krzyszczyk, Charles W Wolgemuth

Abstract

When plated onto a substrate, cells spread. Many cell types, including smooth muscle cells and fibroblasts, spread more effectively on stiffer substrates, and a simple empirical relationship has been determined that relates a cell's spread area to the substrate stiffness. In addition, some crawling cells when plated onto a stiff substrate will not migrate onto soft substrate, a process called "durotaxis". Here we show that the resistive force predicted previously for dynamic adhesion molecules can account for both of these mechanosensory effects.

References

Mar 30, 1999·Biophysical Journal·M Dembo, Y L Wang
Jun 27, 2000·Biophysical Journal·C M LoY L Wang
Aug 23, 2002·Trends in Cell Biology·Bernhard Wehrle-Haller, Beat Imhof
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·I B Bischofs, U S Schwarz
Dec 26, 2003·Biophysical Journal·Adam EnglerDennis Discher
Oct 26, 2005·The Journal of Cell Biology·Caroline CluzelBernhard Wehrle-Haller
Nov 19, 2005·Science·Dennis E DischerYu-Li Wang
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sam Walcott, Sean X Sun
Feb 9, 2011·Physical Biology·Ben HarlandSean X Sun

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Citations

Jun 5, 2019·Soft Matter·Jingchen FengLeonard M Sander
Jan 4, 2020·Nature Physics·Visar AjetiMichael P Murrell

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Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.