Abstract
We previously showed that matrix metalloproteinases (MMPs) contribute to tremendous blood flow-induced venous wall thickening during the maturation of an arteriovenous fistula (AVF). However, how veins in the fistula sense a dramatic change in the blood flow remains unknown. Because mechanosensitive transient receptor potential vanilloid channels (TRPVs) are present in the endothelium, we examined whether the Ca2+-permeable TRPVs play a role in remodeling of fistula veins. The fistula veins were generated at femoral AVF of Wistar rats. Changes in the hemodynamics and the width and internal radius of the iliac vein were studied at 3, 7, 14, and 28 days, then the iliac vein was removed and examined for changes in wall thickness and protein or mRNA expression by immunofluorecent stain, Western blot, or real time PCR. Changes in MMP2 activity was examined by gelatin zymography. Two ligatures were performed in iliac vein to prevent venodilatation to confirm the effect of dramatic changes in hemodynamics on TRPV expression. The specific role of TRPV was studied in another group of fistula veins given with capsazepine via a subcutaneous mini-osmotic pump for 28 days. The fistula veins demonstrated high flow/wall shear stress (WSS), wa...Continue Reading
References
Aug 1, 1996·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·V WongA Bakran
Dec 18, 2001·Cardiovascular Research·Susanne BrakemeierJoachim Hoyer
May 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jean-Marc CorpatauxDaniel Hayoz
Aug 6, 2002·Nature Neuroscience·L A BirderM J Caterina
May 23, 2003·Journal of the American Society of Nephrology : JASN·Klaus KonnerEberhard Ritz
Jul 23, 2004·Physiological Reviews·Gary K OwensBrian R Wamhoff
Oct 23, 2004·Circulation Research·Ramona S ScotlandAmrita Ahluwalia
May 24, 2005·Pflügers Archiv : European journal of physiology·Roger G O'Neil, Stefan Heller
Jun 1, 2005·Current Opinion in Neurobiology·Shuh-Yow Lin, David P Corey
Aug 20, 2005·Circulation Research·Yves CastierStéphanie Lehoux
Sep 16, 2005·Nature·Eleni TzimaMartin Alexander Schwartz
Dec 17, 2005·Circulation Research·Elena OanceaDavid E Clapham
Jan 28, 2006·Circulation Research·B KumarD J Beech
Jul 22, 2006·Circulation Research·Ryuji InoueYushi Ito
Sep 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sorana Ciura, Charles W Bourque
Apr 3, 2007·Journal of Vascular Surgery·Chih-Yang ChanChou-Fong Chen
Jun 27, 2007·British Journal of Pharmacology·A K ChowR Schulz
Jul 25, 2007·Clinical and Experimental Pharmacology & Physiology·William DuranteRobert A Johnson
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Arif AsifGerald A Beathard
Jan 25, 2008·Clinical and Experimental Pharmacology & Physiology·Joseph E BraydenStacey Reading
Apr 9, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Ian N BratzMichael Sturek
May 2, 2008·American Journal of Physiology. Renal Physiology·Ho-Shiang HuangJun Chen
Jan 9, 2009·The EMBO Journal·Thomas Voets, Bernd Nilius
Citations
Aug 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·Na LuoYang Sun
Jun 30, 2014·Journal of Vascular Surgery·Thomas F O'DonnellPeter Gloviczki
Nov 28, 2012·Advances in Medical Sciences·N HimiO Miyamoto
May 15, 2015·Atherosclerosis·Leah C WinkelKim Van der Heiden
Aug 3, 2016·Regenerative Biomaterials·Yi WangGuixue Wang
Jul 28, 2016·Scientific Reports·Yue-Tao LiuZhong-Mei Zou
Apr 3, 2015·Vascular Medicine·Yung-Wei Chi, Joseph D Raffetto
Feb 28, 2015·Circulation Research·Stephan HuveneersPeter L Hordijk
Apr 3, 2015·Physiological Reviews·Scott Earley, Joseph E Brayden
Feb 23, 2020·Channels·Shuo Wang, Chenhong Jia
Feb 11, 2020·Frontiers in Physiology·Sharon NegriFrancesco Moccia
May 19, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Nga Ling KoGeorge Osol
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Jun TakaiHiroto Miura
Sep 8, 2018·Frontiers in Physiology·Charmaine C W LoKristen J Bubb
Mar 17, 2021·The Journal of Pharmacology and Experimental Therapeutics·Yixi LiuChe-Ping Cheng