Mechanotransmission in endothelial cells subjected to oscillatory and multi-directional shear flow

Journal of the Royal Society, Interface
Mahsa DabaghJohn M Tarbell

Abstract

Local haemodynamics are linked to the non-uniform distribution of atherosclerosic lesions in arteries. Low and oscillatory (reversing in the axial flow direction) wall shear stress (WSS) induce inflammatory responses in endothelial cells (ECs) mediating disease localization. The objective of this study is to investigate computationally how the flow direction (reflected in WSS variation on the EC surface over time) influences the forces experienced by structural components of ECs that are believed to play important roles in mechanotransduction. A three-dimensional, multi-scale, multi-component, viscoelastic model of focally adhered ECs is developed, in which oscillatory WSS (reversing or non-reversing) parallel to the principal flow direction, or multi-directional oscillatory WSS with reversing axial and transverse components are applied over the EC surface. The computational model includes the glycocalyx layer, actin cortical layer, nucleus, cytoskeleton, focal adhesions (FAs), stress fibres and adherens junctions (ADJs). We show the distinct effects of atherogenic flow profiles (reversing unidirectional flow and reversing multi-directional flow) on subcellular structures relative to non-atherogenic flow (non-reversing flow). R...Continue Reading

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Citations

Jul 2, 2019·Neurosurgical Focus·Mahsa DabaghAmanda Randles
Mar 13, 2020·APL Bioengineering·Peter J Butler
Sep 23, 2020·Cardiovascular Engineering and Technology·Sheldon WeinbaumJohn M Tarbell
Oct 19, 2019·Biomechanics and Modeling in Mechanobiology·P S ZunA G Hoekstra
Feb 2, 2021·Frontiers in Physiology·Simone Regina PotjeLusiane Maria Bendhack
Jun 3, 2021·International Journal of Molecular Sciences·Katharina UrschelBarbara Dietel
Nov 7, 2020·Journal of Biomechanical Engineering·Mostafa MahmoudiAmirhossein Arzani
May 11, 2021·Surgical Technology International·Stefan EngelhardMichel M P J Reijnen
Nov 12, 2018·ACS Biomaterials Science & Engineering·Bryan D James, Josephine B Allen

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