Meconium and neurotoxicants: searching for a prenatal exposure timing.

Archives of Disease in Childhood
J A Ortega GarcíaJ O Grimalt

Abstract

Exposure to organochlorine compounds (OCs) has been a subject of interest in recent years, given their potential neurotoxicity. Meconium is easily available and accumulates neurotoxicants and/or metabolites from the 12th week of gestation. To determine whether neurotoxicants, specifically OCs, could be detected in serially collected meconium, and to compare the results with those obtained in cord blood samples. A sample of cord blood and three serial stool samples were analysed in 10 newborns. Pentachlorobenzene (PeCB), hexachlorobenzene (HCB), polychlorinated biphenyls (PCBs), dichlorodiphenyl trichloroethane (p,p'-DDT) and its metabolite dichlorodiphenyl dichloroethylene (p,p'-DDE), and hexachlorocyclohexane isomers (alpha-, beta-, gamma-, and delta-HCH) were analysed by gas chromatography. From serial stool collection and analysis in newborns, there was an increase in the concentrations of HCB, p,p'-DDE, PCBs, and beta-HCH between the first and last stools of the newborn. Levels of DDT diminished as pregnancy progressed. Concentrations in cord blood were positively associated with concentrations in meconium for p,p'-DDE and beta-HCH. Meconium is a very useful instrument for the investigation of fetal exposure to neurotoxican...Continue Reading

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Citations

Jul 25, 2006·Archives of Disease in Childhood·J Tuomisto
Jul 25, 2006·Archives of Disease in Childhood·E M OstreaN C Posecion
Jul 13, 2012·Environmental Health : a Global Access Science Source·Margaret SaundersAlena Bartonova
Dec 3, 2014·Annals of Epidemiology·Bo Y Park, Brian K Lee
Sep 28, 2010·Bulletin of Environmental Contamination and Toxicology·Margarita Herrero-MercadoF Hernández-Chalate
Oct 28, 2008·Environment International·Marta Esteban, Argelia Castaño
Apr 4, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F Gil, A F Hernández
Jul 6, 2013·Environmental Science. Processes & Impacts·Anna Sofía VeyheEvert Nieboer
Oct 19, 2019·Environmental Research·Ajda TrdinMilena Horvat
Apr 16, 2021·Journal of Perinatal Medicine·Esther Álvarez-SilvaresElena Martínez-Carballo

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