Meconium-stained amniotic fluid exposure is associated with a lower incidence of offspring long-term infectious morbidity

American Journal of Reproductive Immunology : AJRI
Dorit Paz LevyEyal Sheiner

Abstract

Meconium-stained amniotic fluid (MSAF) is a well-established risk factor for immediate adverse neonatal outcomes and was recently suggested to be associated with microbial invasion of the amniotic cavity. We aimed to determine whether MSAF exposure during labor carries a longer lasting impact on pediatric infectious morbidity. A population-based cohort analysis was performed including all singleton deliveries occurring between 1991 and 2014 at a single tertiary medical center. Exposure was defined as the presence of MSAF during labor. Hospitalizations of the offspring up to the age of 18 years involving infectious diseases were evaluated. A Kaplan-Meier survival curve was used to compare cumulative morbidity and a Cox regression model to control for confounders. During the study period, 243 725 deliveries met the inclusion criteria. Of them, 35 897 (14.7%) involved MSAF. Rate of infectious-related hospitalizations of the offspring was significantly lower in children exposed to MSAF as compared with the unexposed group (10.8% vs 11.1%, P < 0.05). Specifically, hospitalizations involving respiratory infections were significantly less common among the MSAF group (5.1% vs 5.6%, P < 0.001). The survival curve demonstrated significan...Continue Reading

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Citations

Jul 19, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Israel YolesTamar Wainstock
Jun 21, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Nanthida PhattraprayoonTeerapat Ungtrakul
Mar 18, 2021·Pediatric Pulmonology·Gal RodavskyTamar Wainstock

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