MedCo: Enabling Secure and Privacy-Preserving Exploration of Distributed Clinical and Genomic Data

IEEE/ACM Transactions on Computational Biology and Bioinformatics
Jean Louis RaisaroJean-Pierre Hubaux

Abstract

The increasing number of health-data breaches is creating a complicated environment for medical-data sharing and, consequently, for medical progress. Therefore, the development of new solutions that can reassure clinical sites by enabling privacy-preserving sharing of sensitive medical data in compliance with stringent regulations (e.g., HIPAA, GDPR) is now more urgent than ever. In this work, we introduce MedCo, the first operational system that enables a group of clinical sites to federate and collectively protect their data in order to share them with external investigators without worrying about security and privacy concerns. MedCo uses (a) collective homomorphic encryption to provide trust decentralization and end-to-end confidentiality protection, and (b) obfuscation techniques to achieve formal notions of privacy, such as differential privacy. A critical feature of MedCo is that it is fully integrated within the i2b2 (Informatics for Integrating Biology and the Bedside) framework, currently used in more than 300 hospitals worldwide. Therefore, it is easily adoptable by clinical sites. We demonstrate MedCo's practicality by testing it on data from The Cancer Genome Atlas in a simulated network of three institutions. Its p...Continue Reading

Citations

Sep 21, 2019·Nature Biotechnology·Dennis GrishinGeorge M Church
Nov 15, 2019·Current Epidemiology Reports·Christine ChoiratMarianthi-Anna Kioumourtzoglou
Sep 16, 2020·Nature Genetics·Amalio Telenti, Xiaoqian Jiang
Jul 23, 2020·BMC Medical Genomics·Nicholas D Pattengale, Corey M Hudson
Jul 6, 2020·Journal of the American Medical Informatics Association : JAMIA·Romain BeyRaphaël Porcher
Dec 4, 2020·Computers in Biology and Medicine·Chandra Thapa, Seyit Camtepe
Feb 26, 2021·Journal of Medical Internet Research·James ScheibnerJean-Pierre Hubaux
Aug 2, 2021·Journal of the American Medical Informatics Association : JAMIA·Joseph FicekEllen Daley
Aug 14, 2021·BMC Medical Informatics and Decision Making·Felix Nikolaus WirthFabian Prasser
Jan 22, 2022·Methods of Information in Medicine·Reihaneh TorkzadehmahaniJan Baumbach

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Cheryl A Thompson
© 2022 Meta ULC. All rights reserved