PMID: 9185310May 24, 1997Paper

Medetomidine as a premedicant for ketamine, propofol or fentanyl anaesthesia in dogs

The Veterinary Record
L J Hellebrekers, R Sap

Abstract

This study evaluated the quality of anaesthesia and the cardiorespiratory effects induced by the combination of medetomidine with either ketamine, propofol or fentanyl. Medetomidine premedication (1000 or 1500 micrograms/m2 body surface area) was followed by intravenous induction of anaesthesia with ketamine (3.0 mg/kg), propofol (2.0 mg/kg) or fentanyl (2.0 micrograms/kg) in bitches undergoing elective ovariohysterectomy. Anaesthesia was prolonged by incremental doses of the induction agents as necessary. The mean (sem) overall doses (including induction) were 0.09 (0.01) mg/kg/min for ketamine, 0.06 (0.01) mg/kg/min for propofol and 0.07 (0.005) microgram/kg/min for fentanyl during procedures which lasted 88 (6) minutes, 72 (3) minutes and 79 (7) minutes, respectively. At the end of the procedure, medetomidine was antagonised with atipamezole. The quality of anaesthesia, heart rate and arterial blood pressure were recorded continuously and arterial blood gases were measured at intervals. At the end of the procedure, the animals received 10 micrograms/kg buprenorphine intramuscularly for postoperative analgesia. From the adequacy of anaesthesia, the lack of significant adverse side effects and the reliable and rapid recovery i...Continue Reading

References

Apr 4, 1987·The Veterinary Record·S B WatkinsK W Clarke

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Citations

Sep 28, 2007·Veterinary Research Communications·N MiñoA Barreiro
May 23, 1998·Journal of Veterinary Pharmacology and Therapeutics·K A GrimmG J Benson
May 10, 2005·Veterinary Anaesthesia and Analgesia·Joanna C Murrell, Ludo J Hellebrekers
Jan 24, 2008·Veterinary Anaesthesia and Analgesia·Joost J UilenreefLudo J Hellebrekers
May 7, 2010·Journal of Veterinary Pharmacology and Therapeutics·M T BarattaC W Locuson
Mar 17, 2010·Veterinary Anaesthesia and Analgesia·Kathy L MurphyPaul A Flecknell
Aug 27, 2003·The Journal of Veterinary Medical Science·Kazuomi OkuToru Fujinaga
Nov 4, 2000·Journal of the American Veterinary Medical Association·K K SladkyW A Horne
Sep 15, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·P SinghR Pathak
Oct 28, 2017·Veterinary Anaesthesia and Analgesia·Christopher K SmithThomas J Doherty

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