Medex 2015: The key role of cardiac mechanics to maintain biventricular function at high altitude

Experimental Physiology
Claire MaufraisSamuel Verges

Abstract

What is the central question of this study? This study is the first to investigate the effects of high-altitude trekking on biventricular mechanics, including measurements of left ventricular subendocardial and subepicardial function. What is the main finding and its importance? We provide new evidence that an increased contractility and untwisting efficiency, a key element of diastolic function, probably plays a key role in preservation of cardiac function during high-altitude trekking. Persistent increased loading conditions during several weeks at high altitude might have a key role in the appearance of left or right ventricular dysfunction. Cardiac responses to acute hypoxic exposure have been thoroughly investigated. We analysed the effects of high-altitude trekking (i.e. prolonged hypoxic exposure) on biventricular function, including the evaluation of subendocardial and subepicardial function in the left ventricle (LV). Resting evaluations of LV and right ventricular (RV) function and mechanics were assessed by speckle tracking echocardiography on 20 subjects at sea level and at high altitude (5085 m, after a 10 day ascent). Pulmonary artery systolic pressure was increased at high altitude (sea level, 13.1 ± 5.9 mmHg; hi...Continue Reading

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Citations

Mar 25, 2019·Experimental Physiology·Mike Stembridge, Benjamin D Levine
Jan 6, 2021·High Altitude Medicine & Biology·Priya GaurPraveen Vats
Feb 2, 2022·European Journal of Applied Physiology·Benoit ChampigneulleSamuel Verges

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