Media, health workers, and policy makers' relationship and their impact on antimalarial policy adoption: a population genetics perspective.

Malaria Research and Treatment
Allen L MalisaCally Roper

Abstract

Drug resistance negatively impacts malaria treatments, making treatment policy revision unavoidable. So far, studies relating sociopolitical and technical issues on policy change with malaria parasite genetic change are lacking. We have quantified the effect of malaria treatment policy on drug pressure and the influence of the media, policy makers, and health worker relationship on parasite population genetic change in Kilombro/Ulanga district. Cross-sectional surveys of asymptomatic infections conducted before, during and after the switch from chloroquine to sulphadoxine/pyrimethamine were used for genetic analysis of SP resistance genes in 4,513 asymptomatic infections identified, and their frequency change was compared with retrospective study of the documented process of policy change. Highly significant changes of dhfr and dhps resistance alleles occurred within one year of switch to SP first line, followed by a decline of their rate of selection caused by reduction of SP usage, as a result of negative media reports on SP usage and lack of adequate preparations.

References

Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·D J ConwayB M Greenwood
May 1, 2004·Tropical Medicine & International Health : TM & IH·Sarah G StaedkePhilip J Rosenthal
Jun 11, 2004·Tropical Medicine & International Health : TM & IH·Catherine GoodmanPeter Bloland
Aug 25, 2004·Science·Cally RoperTim Anderson
Jun 9, 2005·Tropical Medicine & International Health : TM & IH·Hakim SendagireFred Kironde
Sep 28, 2005·Tropical Medicine & International Health : TM & IH·Jaran EriksenGöran Tomson

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Arlequin
STATA

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.