Medial collateral ligament autografts have increased creep response for at least two years and early immobilization makes this worse

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
G M ThorntonC B Frank

Abstract

Recent evidence has shown that 10-40% of knee joints reconstructed with soft-tissue autografts have a recurrence of abnormal joint laxity over time. One possible explanation is the "stretching out" (or unrecovered creep) of the graft tissue. To test in vitro creep and creep recovery of fresh anatomic ligament autografts in an extra-articular environment, 16 rabbits underwent an orthotopic medial collateral ligament (MCL) autograft procedure to one hindlimb. Three subgroups of animals had either unrestricted cage activity for 1 year (n = 5) or 2 years (n = 5) or pin-immobilization for the first 6 weeks followed by cage activity for the remainder of 1 year (n = 6). Following laxity measurements, to test their creep response, isolated MCL grafts were cyclically and then statically creep tested in vitro at 4.1 MPa, allowed to recover at zero load for 20 min, and finally elongated to failure. Due to differences in cross-sectional area between the grafts and normal MCLs, two normal control groups were tested: stress-matched tested at 4.1 MPa (16.2 N; n = 7) and force-matched tested at 29.1 N (7.1 MPa; n = 6). Ligament grafts had normal laxity but significantly increased creep and decreased creep recovery compared to normal MCLs after...Continue Reading

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Citations

May 25, 2006·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tokifumi MajimaCyril B Frank
Oct 15, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Gail M ThorntonCyril B Frank
Aug 4, 2006·The American Journal of Sports Medicine·Ramprasad PapannagariGuoan Li
Sep 9, 2021·Journal of Biomechanical Engineering·Gabrielle L Clark-PattersonKristin S Miller

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