'Medial defects' in the prenatal human cerebral arteries: an electron microscopic study

Stroke; a Journal of Cerebral Circulation
K Fujimoto

Abstract

Fine structural studies were performed to investigate the histogenesis of human intracranial arteries. Special attention was paid to whether "medial defects" exist in these arteries. Segments of the intracranial extracerebral arteries of normal human embryos (n=6) were examined with transmission electron microscopy. Focal defects of the medial smooth muscle cells were disclosed at every bifurcation of the developing arteries. This configuration persisted until the arteries obtained enough muscle coat. These areas, in which an absence of medial smooth muscle cells (ie, a medial defect) existed, were occupied by fibrous connective tissues of elastin and collagen. The medial defect observed at the arterial bifurcation of the embryos seems to be a development process that accompanies human ontogenesis rather than a congenital anomaly, supporting a possible pathogenesis for intracranial saccular aneurysms.

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Citations

Jun 1, 2006·Journal of Human Genetics·Boris Krischek, Ituro Inoue
Jun 12, 2003·The International Journal of Biochemistry & Cell Biology·Baiping ZhangIan N M Day
Feb 22, 2005·Lancet Neurology·Ynte M RuigrokCisca Wijmenga
Apr 1, 2014·Journal of Computer Assisted Tomography·Young-Jun LeeTae-Sub Chung
Jun 30, 2009·Surgical Neurology·Sung-Pil JooSoo-Han Kim
Dec 6, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jin Soo ChoiHyoung Kyun Rha
Jul 22, 2008·Surgical Neurology·Ljiljana P VasovićZlatibor P Andjelković
Jun 27, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sven GläskerHartmut P H Neumann
Jan 20, 2018·Cardiovascular Research·Juhana Frösen, Anne Joutel
Feb 7, 2001·Brain : a Journal of Neurology·J van Gijn, G J Rinkel

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