Medial hypothalamic nuclei mediate serotonin's inhibitory effect on feeding behavior

Pharmacology, Biochemistry, and Behavior
S F LeibowitzJ S Suh

Abstract

Previous studies have demonstrated that injection of serotonin (5-HT) into the paraventricular nucleus (PVN), specifically at the onset of the active feeding cycle, causes a strong and selective suppression of carbohydrate intake, while producing no change in fat intake and, in some cases, enhancing protein consumption. The purpose of the present investigation was to determine whether this selective inhibitory effect of 5-HT on macronutrient ingestion is localized to a specific brain region, perhaps the PVN, or whether it can also occur in other sites throughout the hypothalamus or in regions outside this structure. A total of 7 hypothalamic and 5 extrahypothalamic areas were examined in brain-cannulated, freely feeding rats maintained on pure macronutrient diets of protein, carbohydrate and fat. The effect of 5-HT, a selective suppression (-55%) of carbohydrate feeding, was replicated in the PVN with a relatively low dose of 2.5 nmoles. Tests in 11 other brain sites demonstrated that this action of 5-HT is not unique to the PVN but is anatomically localized to the medial nuclei of the hypothalamus. Sites outside the hypothalamus, namely, the amygdala, nucleus accumbens, septum, diagonal band of Broca and nucleus reuniens dorsa...Continue Reading

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Citations

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