Medial nucleus tractus solitarius oxytocin receptor signaling and food intake control: the role of gastrointestinal satiation signal processing

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Zhi Yi OngH J Grill

Abstract

Central oxytocin (OT) administration reduces food intake and its effects are mediated, in part, by hindbrain oxytocin receptor (OT-R) signaling. The neural substrate and mechanisms mediating the intake inhibitory effects of hindbrain OT-R signaling are undefined. We examined the hypothesis that hindbrain OT-R-mediated feeding inhibition results from an interaction between medial nucleus tractus solitarius (mNTS) OT-R signaling and the processing of gastrointestinal (GI) satiation signals by neurons of the mNTS. Here, we demonstrated that mNTS or fourth ventricle (4V) microinjections of OT in rats reduced chow intake in a dose-dependent manner. To examine whether the intake suppressive effects of mNTS OT-R signaling is mediated by GI signal processing, rats were injected with OT to the 4V (1 μg) or mNTS (0.3 μg), followed by self-ingestion of a nutrient preload, where either treatment was designed to be without effect on chow intake. Results showed that the combination of mNTS OT-R signaling and GI signaling processing by preload ingestion reduced chow intake significantly and to a greater extent than either stimulus alone. Using enzyme immunoassay, endogenous OT content in mNTS-enriched dorsal vagal complex (DVC) in response to...Continue Reading

References

Dec 1, 1990·Physiology & Behavior·R ArlettiA Bertolini
Sep 1, 1990·The Journal of Physiology·M J McCann, R C Rogers
Jan 1, 1990·The American Journal of Physiology·R LandgrafQ J Pittman
Jan 1, 1989·Peptides·R ArlettiA Bertolini
Aug 1, 1995·The American Journal of Physiology·R E BlackburnJ G Verbalis
Oct 1, 1994·The Journal of Physiology·M J Freund-MercierM J Klein
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R E BlackburnJ G Verbalis
Dec 5, 1998·Brain Research. Developmental Brain Research·E E NelsonJ G Verbalis
Dec 31, 1998·Journal of Neuroendocrinology·M Ludwig
Mar 29, 2001·Physiological Reviews·G Gimpl, F Fahrenholz
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Linda Rinaman, Elizabeth E Rothe
Dec 4, 2003·Brain Research·James E BlevinsDenis G Baskin
Mar 27, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James E BlevinsDenis G Baskin
Oct 3, 2006·Cell Metabolism·Louise E JohnstoneGareth Leng
May 3, 2008·Molecular Endocrinology·Bassil M KublaouiAndrew R Zinn
Jun 4, 2008·Neuroreport·Yuki TakayanagiKatsuhiko Nishimori
Nov 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James H PetersMichael C Andresen
Feb 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masahide YoshidaKatsuhiko Nishimori
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Clémence BlouetGary J Schwartz
Mar 26, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gina L C Yosten, Willis K Samson
Jun 18, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven L BealerWilliam R Crowley
Jul 3, 2010·Pharmacology, Biochemistry, and Behavior·Pawel K OlszewskiAllen S Levine
Oct 8, 2011·PloS One·Nicolas DeblonFrançoise Rohner-Jeanrenaud
Oct 20, 2011·American Journal of Physiology. Endocrinology and Metabolism·Gregory J MortonJames E Blevins
Jun 14, 2012·American Journal of Physiology. Endocrinology and Metabolism·Scott E KanoskiHarvey J Grill
Sep 15, 2012·Trends in Neurosciences·Inga D Neumann, Rainer Landgraf
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Valéry MatarazzoSylvian Bauer

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Citations

Sep 27, 2015·Frontiers in Neuroendocrinology·Amanda E Elson, Richard B Simerly
May 21, 2016·Frontiers in Computational Neuroscience·Shayan Tabe-Bordbar, Thomas J Anastasio
Jul 28, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zachary S RobertsJames E Blevins
Apr 17, 2018·Neuroendocrinology·Yuko MaejimaKenju Shimomura
Feb 27, 2018·Journal of Neuroendocrinology·Monica LeslieJanet Treasure
Aug 16, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zhi Yi OngHarvey J Grill
Jun 22, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Takeshi IwasaMinoru Irahara
Aug 12, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Willis K Samson
Oct 28, 2019·Journal of Neuroendocrinology·Elizabeth A LawsonJames E Blevins
Dec 6, 2019·Endocrine Reviews·Shana E McCormackElizabeth A Lawson
Dec 5, 2019·Scientific Reports·Yuko MaejimaKenju Shimomura
Nov 18, 2018·The Journal of Clinical Endocrinology and Metabolism·Anna AulinasElizabeth A Lawson
May 20, 2020·Clinical Medicine Insights. Endocrinology and Diabetes·Andrew English, Nigel Irwin
Oct 28, 2018·Science China. Life Sciences·Song WenLigang Zhou
Jul 10, 2019·Journal of the Endocrine Society·Brandy SniderMinrong Ai
Apr 15, 2016·World Journal of Gastroenterology : WJG·Quan-Jun DengYong-Yu Lu
Jan 27, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lily R BarrettXiaobing Zhang
Oct 8, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hallie S WaldHarvey J Grill
Jan 21, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melise M EdwardsJames E Blevins
Jul 25, 2021·International Journal of Molecular Sciences·Liya Kerem, Elizabeth A Lawson

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