Medial or lateral orbitofrontal cortex activation during fear extinction differentially regulates fear renewal.

Behavioural Brain Research
Cheng-Wei Shih, Chun-Hui Chang

Abstract

Some anxiety-related disorders, such as panic disorder, specific phobia, post-traumatic stress disorder (PTSD), and obsessive-compulsive disorder (OCD), develop because of the poor regulation and inappropriate expression of fear-related behavior at the wrong place and wrong time. In clinical settings, exposure therapy, which consists of repeated presentation of trauma-related stimuli without real threats in the therapeutic context, is commonly used to treat these disorders. However, 30-50 % of patients suffer from the recurrence of anxiety symptoms after they leave the therapeutic context. This behavioral phenomenon is called renewal. In this study, ABA Pavlovian fear renewal paradigm was used to assess the role of the aberrant orbitofrontal cortex (OFC) activation, a symptom of OCD patients, on fear regulation in laboratory settings. The rats were fear conditioned in one context (context A), extinguished to the tones in another context (context B), and then tested in either context A or B. During extinction, rats were subjected to lateral or medial OFC activation. We found that rats that underwent extinction with either lateral or medial OFC activation were unable to use the context to determine whether it was a safe or danger...Continue Reading

References

Oct 1, 1979·Journal of Experimental Psychology. Animal Behavior Processes·M E Bouton, R C Bolles
Dec 3, 1976·Brain Research·D A Chavis, D N Pandya
Sep 19, 1998·The Journal of Comparative Neurology·C J Shi, M D Cassell
Mar 24, 2000·Cerebral Cortex·C CavadaF Reinoso-Suárez
Feb 7, 2001·Current Opinion in Neurobiology·C Büchel, R J Dolan
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Nov 25, 2000·Depression and Anxiety·K RowaR P Swinson
Aug 25, 2001·Annual Review of Neuroscience·S Maren
Apr 30, 2002·American Journal of Psychotherapy·Barbara Olasov Rothbaum, Ann C Schwartz
Oct 22, 2003·NeuroImage·Morten L Kringelbach, Edmund T Rolls
May 26, 2004·Progress in Neurobiology·Morten L Kringelbach, Edmund T Rolls
Jun 24, 2004·Journal of Neurophysiology·Denis ParéJoseph E Ledoux
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alicia IzquierdoElisabeth A Murray
Oct 7, 2004·Learning & Memory·Mark E Bouton
Oct 16, 2004·Science·K Richard RidderinkhofSander Nieuwenhuis
Sep 30, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin A CorcoranStephen Maren
Sep 1, 2006·Neural Networks : the Official Journal of the International Neural Network Society·Matthias BrandHans J Markowitsch
Nov 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephen Maren, Chun-hui Chang
Dec 13, 2006·Molecular Psychiatry·K M Myers, M Davis
Jun 15, 2007·The Journal of Nervous and Mental Disease·Peter J Norton, Esther C Price
Aug 19, 2007·Annals of the New York Academy of Sciences·Mohammed R Milad, Scott L Rauch
Sep 12, 2007·Annals of the New York Academy of Sciences·Nancy L Rempel-Clower
Sep 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregory J Quirk, Devin Mueller
Sep 25, 2007·Biological Psychiatry·Philippe R GoldinJames J Gross
Mar 28, 2008·The Journal of Clinical Psychiatry·Stefan G Hofmann, Jasper A J Smits
Jul 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa M Shin, Israel Liberzon
Mar 12, 2010·Brain Structure & Function·H J J M Van De WerdHarry B M Uylings
Nov 3, 2010·Cerebral Cortex·Philipp KanskeMichèle Wessa
Jul 30, 2011·The Journal of Comparative Neurology·Walter B Hoover, Robert P Vertes
Aug 26, 2011·The American Journal of Psychiatry·Bronwyn M Graham, Mohammed R Milad
Nov 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caitlin A OrsiniStephen Maren
Apr 29, 2015·Nature Neuroscience·Thomas A StalnakerGeoffrey Schoenbaum
Oct 9, 2015·Neuron·Joseph E DunsmoorElizabeth A Phelps
Jan 7, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Anton HenssenKatrin Amunts
Jan 14, 2017·The European Journal of Neuroscience·Stacey A BedwellChris J Tinsley
Nov 3, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alicia Izquierdo
Jan 3, 2018·Neurobiology of Learning and Memory·Yu-Hsuan ChangChun-Hui Chang
Jan 13, 2018·Nature Communications·Hiroshi YamadaPaul W Glimcher
Nov 1, 2018·Psychopharmacology·Nicolas Singewald, Andrew Holmes
Nov 8, 2018·Journal of Psychiatry & Neuroscience : JPN·Huimeng LeiGuoping Feng
Jan 25, 2020·Neurobiology of Learning and Memory·Hsin-Ti Hsieh, Chun-Hui Chang

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