Medial Prefrontal Cortex: Adding Value to Imagined Scenarios

Journal of Cognitive Neuroscience
Wen-Jing LinNeil Burgess

Abstract

The medial prefrontal cortex (mPFC) is consistently implicated in the network supporting autobiographical memory. Whereas more posterior regions in this network have been related to specific processes, such as the generation of visuospatial imagery or the association of items and contexts, the functional contribution of the mPFC remains unclear. However, the involvement of mPFC in estimation of value during decision-making suggests that it might play a similar role in memory. We investigated whether mPFC activity reflects the subjective value of elements in imagined scenarios. Participants in an MRI scanner imagined scenarios comprising a spatial context, a physiological state of need (e.g., thirst), and two items that could be congruent (e.g., drink) or incongruent (e.g., food) with the state of need. Memory for the scenarios was tested outside the scanner. Our manipulation of subjective value by imagined need was verified by increased subjective ratings of value for congruent items and improved subsequent memory for them. Consistent with our hypothesis, fMRI signal in mPFC reflected the modulation of an item's subjective value by the imagined physiological state, suggesting the mPFC selectively tracked subjective value within...Continue Reading

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May 16, 2017·Psychological Science·Adrianna C Jenkins, Ming Hsu
Jun 25, 2016·Scientific Reports·Wen-Jing LinNeil Burgess
Nov 14, 2019·The International Journal of Neuropsychopharmacology·Stephanie M GorkaSubhash C Pandey
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Apr 30, 2019·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Margot LouailSebastien Bouret
May 1, 2021·Cognitive Neuroscience·Aleea L DevittDaniel L Schacter

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