Medial prefrontal cortex and dorsomedial striatum are necessary for the trial-unique, delayed nonmatching-to-location (TUNL) task in rats: role of NMDA receptors

Learning & Memory
Don A DaviesJohn G Howland

Abstract

The trial-unique, delayed nonmatching-to-location (TUNL) task is a recently developed behavioral task that measures spatial working memory and a form of pattern separation in touchscreen-equipped operant conditioning chambers. Limited information exists regarding the neurotransmitters and neural substrates involved in the task. The present experiments tested the effects of systemic and intracranial injections of NMDA receptor antagonists on the TUNL task. After training, male Long Evans rats systemically injected with the competitive NMDA receptor antagonist CPP (10 mg/kg) had impaired accuracy regardless of the degree of stimuli separation or length of delay between the sample and test phases. Injections of Ro 25-6981 (6 or 10 mg/kg), an antagonist selective for GluN2B subunit-containing NMDA receptors, did not affect accuracy on the task. Direct infusion of the competitive NMDA receptor antagonist AP5 into mPFC or dmSTR reduced overall accuracy on the TUNL task. These results demonstrate that TUNL task performance depends on NMDA receptors within the mPFC and dmSTR.

References

Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·H B LiH Watanabe
Nov 20, 1997·Brain : a Journal of Neurology·C PantelisT W Robbins
Jun 4, 2004·Behavioral Neuroscience·William E DeCoteauRaymond P Kesner
Apr 21, 2006·The European Journal of Neuroscience·Raymond P Kesner, Paul E Gilbert
Aug 26, 2006·Science·Jonathan R WhitlockMark F Bear
Jun 17, 2008·Neuropsychologia·Henry W ChaseTrevor W Robbins
Oct 15, 2009·Neurobiology of Learning and Memory·Boyer D WintersTimothy J Bussey
Oct 28, 2009·Neurobiology of Learning and Memory·John G Howland, Brittany N Cazakoff
Nov 16, 2010·Neurobiology of Learning and Memory·Dave A MacQueenMark Galizio
Jun 21, 2011·Learning & Memory·Roula MoussaFrancesca Sargolini
Oct 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Samantha L RushforthMohammed Shoaib
Jun 23, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mazen A KheirbekRené Hen
Nov 19, 2013·Learning & Memory·Don A DaviesJohn G Howland
Dec 19, 2013·Frontiers in Behavioral Neuroscience·Don A DaviesJohn G Howland
Jul 6, 2015·Neuroscience and Biobehavioral Reviews·Sarah A MonacoWen-Jun Gao

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Citations

Apr 30, 2020·Genes, Brain, and Behavior·Gavin A ScottJohn G Howland
Jan 9, 2019·Frontiers in Systems Neuroscience·Sara N BurkeAndrew P Maurer
Feb 20, 2021·Hippocampus·Sarah A JohnsonSara N Burke
Dec 22, 2020·ACS Pharmacology & Translational Science·Cassandra J HatzipantelisChristopher J Langmead

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