Medial prefrontal cortex and nucleus accumbens core are involved in retrieval of the methamphetamine-associated memory

Behavioural Brain Research
Chih-Yuan ChiangLung Yu

Abstract

Immunohistochemical Fos staining has proven to be a method to identify the neurons that are activated by stimulation. Although methamphetamine (MA)-conditioned place preference (CPP) memory was long-lasting, how this memory was established and retrieved remained unknown. We used the vehicle- and MA-conditioned environment (including cues and context) to reactivate the MA-CPP memory in mice. In the limbic system, Fos-positive neurons were examined following retrieval of the MA-CPP memory. We demonstrated that the current conditioning procedure produced reliable MA-CPP performance. Moreover, enhanced Fos expressions were found in the medial prefrontal cortex and the core of the nucleus accumbens after reactivation of the MA-CPP memory. Furthermore, familiarity with the environmental cues/context was found to significantly enhance Fos expressions in dorsal striatum and dentate gyrus. Nucleus accumbens shell, basolateral or lateral amygdala, in this regard, did not seem to be involved in retrieval of the MA-CPP memory. These results, taken together, suggest that the medial prefrontal cortex and the core of the nucleus accumbens are anatomical substrates responsible for reactivation of the MA-CPP memory.

References

Mar 1, 1989·Journal of Cellular Physiology·R J VosatkaE B Ziff
Oct 2, 1998·Neuroscience Letters·A N ToppleI S McGregor
Jan 19, 1999·The American Journal of Psychiatry·A R ChildressC P O'Brien
Jul 9, 2002·The European Journal of Neuroscience·Bernard Le FollPierre Sokoloff
Dec 10, 2002·Archives of General Psychiatry·Arthur L BrodyMurray E Jarvik
Aug 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Courtney A Miller, John F Marshall
Jun 2, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan L C LeeBarry J Everitt
Aug 15, 2006·Neurobiology of Learning and Memory·Yu-Min KuoLung Yu
Aug 22, 2006·Behavioural Brain Research·Matthew W Feltenstein, Ronald E See
Aug 26, 2006·Neuroreport·Rick E BernardiStephen P Berger
Sep 29, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yu ZhaoFriedbert Weiss
May 2, 2007·Neuroreport·Jonathan B KelleyYossef Itzhak
Jun 19, 2007·Behavioural Brain Research·Chianfang G CherngLung Yu
Sep 1, 2007·Science·Leon G ReijmersMark Mayford
Mar 4, 2008·British Journal of Pharmacology·M W Feltenstein, R E See
Mar 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ryan T LaLumiere, Peter W Kalivas
Dec 3, 2014·European Psychiatry : the Journal of the Association of European Psychiatrists·P Y TsengY K Yang

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Citations

Apr 6, 2011·Behavioral Neuroscience·Robin M VoigtT Celeste Napier
Mar 25, 2015·Drug and Alcohol Dependence·Peng XuWeidong Li
Nov 5, 2013·Biological Psychiatry·Argel Aguilar-VallesCourtney A Miller
Dec 4, 2019·The Chinese Journal of Physiology·Chianfang G Cherng, Lung Yu

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