Medial prefrontal cortex modulation of the baroreflex parasympathetic component in the rat

Brain Research
L B M ResstelF M A Corrêa

Abstract

The ventral portion of the medial prefrontal cortex (vMPFC) that comprises the prelimbic and infralimbic cortex is involved in arterial blood pressure and heart rate control. In the present study, we attempted to verify the effect of an acute and reversible blockade of vMPFC activity by local bilateral microinjections of either lidocaine (a local anesthetic) or CoCl2 (a nonselective synapse blocker) on the baroreflex response of unanesthetized rats. Bilateral microinjection of lidocaine into the vMPFC did not affect the tachycardiac response to mean arterial pressure (MAP) decreases caused by i.v. infusion of sodium nitroprusside or the baroreflex gain in unanesthetized rats. However, lidocaine caused a reversible shift of the reflex threshold pressure toward higher (MAP) increases in response to i.v. infusion of phenylephrine, thus indicating an action on the parasympathetic component of the baroreflex. The effects of the blockade of local synapses in the vMPFC by CoCl2 were similar to those observed after the acute ablation of that area caused by lidocaine. Bilateral microinjection of CoCl2 into the vMPFC also caused a shift of the reflex threshold pressure bradycardiac responses to MAP increases toward higher MAP values, wit...Continue Reading

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Citations

Apr 10, 2012·Cellular and Molecular Neurobiology·América A ScopinhoFernando M A Corrêa
Oct 4, 2011·Cerebral Cortex·Paul M MaceyRonald M Harper
Apr 24, 2008·Clinical and Experimental Pharmacology & Physiology·Leonardo B M ResstelFernando M A Corrêa
May 6, 2009·Clinical and Experimental Pharmacology & Physiology·Carlos C CrestaniFernando M A Correa
Jan 13, 2010·Biomedical Engineering Online·B Silvano ZanuttoEnrique T Segura
Jul 14, 2010·European Journal of Medical Research·V G AleksandrovN P Aleksandrova
Sep 8, 2006·Neuroreport·Carlos C CrestaniFernando M de A Corrêa
Mar 5, 2013·Physiology & Behavior·Robert S ThompsonMonika Fleshner
Sep 12, 2015·British Journal of Pharmacology·D C LagattaL B M Resstel
Feb 15, 2011·Physiology & Behavior·Eduardo F Carvalho-NettoJames P Herman
Feb 17, 2009·Autonomic Neuroscience : Basic & Clinical·Fernando H F AlvesFernando M A Correa
Aug 19, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Francesca BosciaLucio Annunziato
Oct 29, 2008·Neuroscience Letters·Carlos C CrestaniFernando M A Corrêa
Oct 5, 2007·Autonomic Neuroscience : Basic & Clinical·América Augusto ScopinhoFernando Morgan Aguiar Correa
Jan 20, 2006·The European Journal of Neuroscience·L B M Resstel, F M A Corrêa
Apr 21, 2007·Annals of the New York Academy of Sciences·L AnnunziatoG F Di Renzo
Dec 22, 2005·The European Journal of Neuroscience·Gislaine Garcia Pelosi, Fernando Morgan Aguiar Corrêa
Dec 20, 2011·Experimental Physiology·América A ScopinhoCarlos C Crestani
May 4, 2011·The European Journal of Neuroscience·Eduardo Albino Trindade FortalezaFernando Morgan de Aguiar Corrêa
Jul 19, 2012·The European Journal of Neuroscience·América A ScopinhoFernando M A Corrêa
Feb 22, 2011·Experimental Physiology·Erica M GranjeiroLeonardo B M Resstel
Apr 1, 2010·Brain Research·Fernando H F AlvesFernando M A Corrêa
Oct 3, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dmitry M DavydovIris Goldstein
Jul 28, 2015·Autonomic Neuroscience : Basic & Clinical·Eduardo Albino Trindade FortalezaFernando Morgan Aguiar Corrêa
Apr 11, 2006·Autonomic Neuroscience : Basic & Clinical·L B M Resstel, F M A Corrêa
Sep 22, 2015·Frontiers in Physiology·J Kevin Shoemaker, Ruma Goswami

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