Medial temporal lobe atrophy predicts Alzheimer's disease in patients with minor cognitive impairment

Journal of Neurology, Neurosurgery, and Psychiatry
P J VisserJ Jolles

Abstract

To investigate whether medial temporal lobe atrophy predicted outcome in patients with minor cognitive impairment and whether assessment of the medial temporal lobe could increase the predictive accuracy of age and delayed recall for outcome. Quantitative and qualitative methods of assessing the medial temporal lobe were also compared. Patients with minor cognitive impairment older than 50 years (n=31) were selected from a memory clinic and were followed up for on average 1.9 years. The medial temporal lobe was assessed in three different ways: volumetry of the hippocampus, volumetry of the parahippocampal gyrus, and qualitative rating of medial temporal lobe atrophy (MTA). Outcome measures were Alzheimer type dementia or cognitive decline at follow up. Delayed recall was tested with a verbal learning test. Ten patients had experienced cognitive decline at follow up, of whom seven had probable Alzheimer type dementia. All medial temporal lobe measurements were associated with cognitive decline at follow up (p trend analysis between 0.001 (hippocampus) and 0.05 (parahippocampal gyrus)). Only the hippocampal volume and MTA score were associated with Alzheimer type dementia at follow up (p trend analysis respectively 0.003 and 0.0...Continue Reading

Citations

Jan 24, 2015·AJNR. American Journal of Neuroradiology·N ChowUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 8, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Janelle T ForetAndreana P Haley
Jul 30, 2021·Frontiers in Aging Neuroscience·Panteleimon GiannakopoulosFrançois R Herrmann

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