Median effective dose of isoflurane, sevoflurane, and desflurane in green iguanas

American Journal of Veterinary Research
Linda S BarterBruno H Pypendop

Abstract

To determine the median effective dose (ED(50); equivalent to the minimum alveolar concentration [MAC]) of isoflurane, sevoflurane, and desflurane for anesthesia in iguanas. 6 healthy adult green iguanas. In unmedicated iguanas, anesthesia was induced and maintained with each of the 3 volatile drugs administered on separate days according to a Latin square design. Iguanas were endotracheally intubated, mechanically ventilated, and instrumented for cardiovascular and respiratory measurements. During each period of anesthesia, MAC was determined in triplicate. The mean value of 2 consecutive expired anesthetic concentrations, 1 that just permitted and 1 that just prevented gross purposeful movement in response to supramaximal electrical stimulus, and that were not different by more than 15%, was deemed the MAC. Mean +/- SD values for the third MAC determination for isoflurane, sevoflurane, and desflurane were 1.8 +/- 0.3%, 3.1 +/- 1.0%, and 8.9 +/- 2.1% of atmospheric pressure, respectively. The MAC for all inhaled agents was, on average, 22% greater for the first measurement than for the third measurement. Over time, MACs decreased for all 3 agents. Final MAC measurements were similar to values reported for other species. The de...Continue Reading

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Citations

Oct 4, 2006·American Journal of Veterinary Research·Robert J BrosnanMichelle G Hawkins
Aug 29, 2012·American Journal of Veterinary Research·Kristen A PhairBruno H Pypendop
May 29, 2014·American Journal of Veterinary Research·Trevor T ZachariahMaureen A McMichael
Jun 20, 2007·The Veterinary Clinics of North America. Exotic Animal Practice·David Martinez-Jimenez, Stephen J Hernandez-Divers
Nov 22, 2018·Scientific Reports·Eva Maria GreunzMads Frost Bertelsen
Oct 17, 2020·Journal of the American Veterinary Medical Association·Lauren P KaneMatthew C Allender

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