Mediastinal nonlymphoblastic lymphomas in children: a clinicopathologic study

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
N J BuninS B Murphy

Abstract

The records of 25 pediatric patients with mediastinal nonlymphoblastic lymphoma (NLBL) were reviewed. These patients comprise approximately 5% of all patients with non-Hodgkin's lymphoma (NHL) in the pediatric age group. There were 15 females and ten males. The median age was 13.5 years (range, 2 to 19). Most patients presented with symptoms attributable to a large mediastinal mass, and superior vena cava syndrome was a common feature. Disease was localized to the supradiaphragmatic area in 17 patients (71%) at diagnosis. Pathologic review revealed 22 of these lymphomas to be diffuse histiocytic type in the Rappaport classification, and 20 were large-cell immunoblastic type in the Working Formulation. Treatment regimens were not uniform, but included multiagent chemotherapy in 23 patients and radiation to the mediastinum in 20 patients. Twenty-three patients (92%) attained a complete remission (CR). Of these, 17 (74%) remain disease-free 13 to 65 months from diagnosis (median, 43 months). No CNS relapses have been observed. Mediastinal NLBL in the pediatric age group has distinctive clinicopathologic features that warrant special consideration in the design of treatment protocols.

Citations

Nov 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A LonesM S Cairo
Jul 1, 1994·Hematological Oncology·J RodriguezF Cabanillas
May 22, 2002·Indian Journal of Pediatrics·L S AryaM Bhargawa
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A A Abou-ElellaJ O Armitage
Jun 1, 1993·Journal of Clinical Pathology·T F CarrA M Kelsey
Dec 3, 1999·British Journal of Haematology·C R Pinkerton
Jul 1, 1995·Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association·T PiiraC R Kjeldsberg

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