MEDIASTinal staging of non-small cell lung cancer by endobronchial and endoscopic ultrasonography with or without additional surgical mediastinoscopy (MEDIASTrial): study protocol of a multicenter randomised controlled trial.

BMC Surgery
Jelle E BousemaMEDIASTrial study group

Abstract

In case of suspicious lymph nodes on computed tomography (CT) or fluorodeoxyglucose positron emission tomography (FDG-PET), advanced tumour size or central tumour location in patients with suspected non-small cell lung cancer (NSCLC), Dutch and European guidelines recommend mediastinal staging by endosonography (endobronchial ultrasound (EBUS) and endoscopic ultrasound (EUS)) with sampling of mediastinal lymph nodes. If biopsy results from endosonography turn out negative, additional surgical staging of the mediastinum by mediastinoscopy is advised to prevent unnecessary lung resection due to false negative endosonography findings. We hypothesize that omitting mediastinoscopy after negative endosonography in mediastinal staging of NSCLC does not result in an unacceptable percentage of unforeseen N2 disease at surgical resection. In addition, omitting mediastinoscopy comprises no extra waiting time until definite surgery, omits one extra general anaesthesia and hospital admission, and may be associated with lower morbidity and comparable survival. Therefore, this strategy may reduce health care costs and increase quality of life. The aim of this study is to compare the cost-effectiveness and cost-utility of mediastinal staging s...Continue Reading

References

Jun 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ramón Rami-PortaUNKNOWN International Association for the Study of Lung Cancer (IASLC) Staging Committee
Mar 22, 2007·Journal of the National Cancer Institute·Jan P van MeerbeeckUNKNOWN European Organisation for Research and Treatment of Cancer-Lung Cancer Group
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Feb 21, 2013·The Korean Journal of Thoracic and Cardiovascular Surgery·Deok Heon LeeChang Kwon Park
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Nov 11, 2017·Frontiers in Oncology·Paul E Van SchilPatrick Lauwers

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Citations

Nov 14, 2018·Panminerva Medica·Piero CandoliLorenzo Corbetta
Dec 2, 2020·Interactive Cardiovascular and Thoracic Surgery·Ian DiebelsPaul E Y Van Schil
Feb 1, 2021·Interactive Cardiovascular and Thoracic Surgery·Michiel A IJsseldijkMarnix A J de Roos
May 6, 2021·Current Oncology·Christopher J L StoneGeneviève C Digby
May 2, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M P J VisserJ Janssen
Jun 9, 2021·Chest·David J HeinemanWilhelmina H Schreurs
May 25, 2021·Chest·Farhood Farjah, Nichole T Tanner
Jun 4, 2020·Respiration; International Review of Thoracic Diseases·Roel Lambertus Johannes VerhoevenErik H F M van der Heijden

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Methods Mentioned

BETA
biopsy
surgical resection
dissection

Software Mentioned

Research Manager
MEDIASTrial
EBUSAT
IKNL
ToetsingOnline

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