Mediastinal staging of non-small-cell lung cancer: computed tomography and cervical mediastinoscopy

ORL; Journal for Oto-rhino-laryngology and Its Related Specialties
C AabyS M Nielsen

Abstract

The exact indications for computed tomography (CT) of the thorax and mediastinoscopy (MS) in lung cancer still remain incompletely defined. The present study was designed to establish a standard approach to cervical MS for otolaryngologists, who in Denmark are traditionally involved in the staging of non-small-cell lung cancer (NSCLC). Sixty-four potentially operable patients with NSCLC underwent thoracic CT prior to bronchoscopy and cervical MS. Cervical MS alone established the histological diagnosis in 20% of the patients. In diagnosing lymph node metastases in the superior mediastinum, a criterion of 10 mm for abnormal enlargement resulted in an overall sensitivity and specificity of mediastinal CT of 81 and 84%, respectively, and the overall false-negative and false-positive rates appeared to be 10 and 29%, respectively. It could be demonstrated that mediastinal lymph nodes in patients with mediastinal metastases were significantly larger than mediastinal lymph nodes in patients without metastases. No clinicopathological characteristics could be identified to influence the accuracy of CT, except for the finding that the rate of false-negative mediastinal CT was significantly higher in patients with right-sided than in pati...Continue Reading

Citations

Jan 28, 2004·Gastrointestinal Endoscopy·John DewittStuart Sherman
Jun 11, 2002·Current Opinion in Pulmonary Medicine·John M Barker, Gerard A Silvestri
Oct 27, 2004·American Journal of Respiratory and Critical Care Medicine·Julia K LeBlancEdith Collins
Jan 16, 2003·Chest·Frank C DetterbeckUNKNOWN American College of Chest Physicians
Oct 6, 2007·Chest·Gerard A SilvestriUNKNOWN American College of Chest Physicians
Oct 6, 2007·Chest·Frank C DetterbeckUNKNOWN American College of Chest Physicians

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