Jan 29, 2015

Mediated pleiotropy between psychiatric disorders and autoimmune disorders revealed by integrative analysis of multiple GWAS

BioRxiv : the Preprint Server for Biology
Qian WangHongyu Zhao

Abstract

Epidemiological observations and molecular-level experiments have indicated that brain disorders in the realm of psychiatry may be influenced by immune dysregulation. However, the degree of genetic overlap between immune disorders and psychiatric disorders has not been well established. We investigated this issue by integrative analysis of genome-wide association studies (GWAS) of 18 complex human traits/diseases (five psychiatric disorders, seven autoimmune disorders, and others) and multiple genomewide annotation resources (Central nervous system genes, immune-related expressionquantitative trait loci (eQTL) and DNase I hypertensive sites from 98 cell-lines). We detected pleiotropy in 24 of the 35 psychiatric-autoimmune disorder pairs, with statistical significance as strong as p =3.9e-285 (schizophrenia-rheumatoid arthritis). Strong enrichment (>1.4 fold) of immune-related eQTL was observed in four psychiatric disorders. Genomic regions responsible for pleiotropy between psychiatric disorders and autoimmune disorders were detected. The MHC region on chromosome 6 appears to be the most important (and it was indeed previously noted ([1][1]-[3][2]) as a confluence between schizophrenia and immune disorder risk regions), with ma...Continue Reading

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Mentioned in this Paper

Anagallis arvensis
Genome-Wide Association Study
Quantitative Trait Loci
Treatment Protocols
Brain Diseases
Deoxyribonuclease I
Immune System Diseases
Genome
Genes
Schizophrenia

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