Mediation Analysis as a Means of Identifying Dietary Components That Differentially Affect the Fecal Microbiota of Infants Weaned by Modified Baby-Led and Traditional Approaches

Applied and Environmental Microbiology
Claudia LeongAnne-Louise M Heath

Abstract

The introduction of "solids" (i.e., complementary foods) to the milk-only diet in early infancy affects the development of the gut microbiota. The aim of this study was to determine whether a "baby-led" approach to complementary feeding that encourages the early introduction of an adult-type diet results in alterations of the gut microbiota composition compared to traditional spoon-feeding. The Baby-Led Introduction to SolidS (BLISS) study randomized 206 infants to BLISS (a modified version of baby-led weaning [BLW], the introduction of solids at 6 months of age, followed by self-feeding of family foods) or control (traditional spoon-feeding of purées) groups. Fecal microbiotas and 3-day weighed-diet records were analyzed for a subset of 74 infants at 7 and 12 months of age. The composition of the microbiota was determined by sequencing of 16S rRNA genes amplified by PCR from bulk DNA extracted from feces. Diet records were used to estimate food and dietary fiber intake. Alpha diversity (number of operational taxonomic units [OTUs]) was significantly lower in BLISS infants at 12 months of age (difference [95% confidence interval {CI}] of 31 OTUs [3.4 to 58.5]; P = 0.028), and while there were no significant differences between ...Continue Reading

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Citations

Nov 12, 2019·The American Journal of Clinical Nutrition·Claudia LeongRachael W Taylor
Jul 3, 2020·Frontiers in Cellular and Infection Microbiology·Thilini N JayasingheJustin M O'Sullivan
Jan 24, 2020·European Journal of Clinical Nutrition·Anne-Louise M HeathGerald W Tannock
Dec 24, 2020·Applied and Environmental Microbiology·Gerald W Tannock
Sep 2, 2021·Applied and Environmental Microbiology·Gerald W Tannock

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