Mediation analysis for the relationship between urinary phthalate metabolites and type 2 diabetes via oxidative stress in a population in Jeddah, Saudi Arabia.

Environment International
Adela Jing LiKurunthachalam Kannan

Abstract

Human exposure to phthalates is ubiquitous and has received considerable attention due to their association with adverse health outcomes, including type 2 diabetes mellitus (T2DM). Nevertheless, earlier studies that link phthalate exposure to T2DM yielded ambiguous results. Furthermore, studies that associate phthalate exposure with oxidative stress and then with T2DM are scant. In this diabetic case-control study, urine samples collected from 101 individuals aged 28-68 years from Jeddah, Saudi Arabia, were analyzed to determine 20 phthalate metabolites (PhMs) and seven oxidative stress biomarkers (OSBs). Unconditional logistic regression was used to estimate odds ratios for the association between diabetes and urinary PhMs and OSBs in participants, stratified by age, gender, nationality, smoking status, occupation, and urinary creatinine. Twelve PhMs and five OSBs were found at detection rates above 50%, with geometric mean concentrations of 0.61-100 and 0.35-10.7 ng/mL (1.04-171 and 0.61-18.6 μg/g creatinine), respectively. Almost all exposures were significantly higher in diabetic cases than in controls. The 12 PhMs were positively associated with higher urinary concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-is...Continue Reading

Citations

Jun 11, 2020·Scientific Reports·Thomas P van der MeerJana V van Vliet-Ostaptchouk
May 1, 2021·International Journal of Environmental Research and Public Health·Po-Chin HuangChing-Chang Lee
Jun 8, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Katarina BaralićDanijela Đukić-Ćosić
Sep 10, 2021·Environmental Science and Pollution Research International·Hui GaoMiao Zang
Jan 27, 2022·Environmental Science and Pollution Research International·Ana Socorro Rodríguez-BáezRogelio Flores-Ramírez

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