Mediation by prostaglandins of the nitric oxide-induced neurogenic vasodilatation in rat skin

British Journal of Pharmacology
P HolzerB A Peskar

Abstract

1. Intraplantar administration of the nitric oxide (NO) donor, sodium nitroprusside (SNP), induces hyperaemia in the rat paw skin, which is in part due to release of calcitonin gene-related peptide (CGRP) from afferent nerve fibres. The present study examined whether prostaglandins or other inflammatory mediators participate in the neurogenic vasodilatation caused by SNP. Blood flow in the plantar hindpaw skin of urethane-anaesthetized rats was measured by laser Doppler flowmetry. 2. The hyperaemic responses to intraplantar administration of the NO donors SNP (150 pmol) and 3-morpholino-sydnonimine (SIN-1, 15 nmol) were attenuated by 45% and 61%, respectively, after injection of the CGRP antagonist, CGRP8-37 (50 nmol kg-1, i.v.) which did not significantly change baseline blood flow. 3. The NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 15 mg kg-1, i.v.), the bradykinin antagonist Hoc-140 (100 nmol kg-1, i.v.) and the histamine antagonists, pyrilamine (2 mg kg-1, i.v.) plus cimetidine (10 mg kg-1, i.p.) were without effect on baseline blood flow and the vasodilatation caused by SNP. 4. The cyclo-oxygenase inhibitors, indomethacin (10 mg kg-1, i.p.) and flurbiprofen (5 mg kg-1, i.p.) depressed the SNP-induced hy...Continue Reading

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Citations

Dec 9, 2003·European Journal of Pharmacology·Ken-ichi HayashiKoichi Nakayama
Feb 11, 1998·General Pharmacology·P Holzer
Nov 5, 1997·Journal of Pain and Symptom Management·M Anbar, B M Gratt
Jul 15, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M Anbar, B M Gratt
Aug 28, 2002·The Journal of Pharmacy and Pharmacology·Paolo TucciPaola Bolle
May 23, 2012·The American Journal of Pathology·Mahrukh M SyedaYuling Chi
Apr 17, 2014·Antioxidants & Redox Signaling·Nikita Gamper, Lezanne Ooi
Jul 27, 2001·Diabetes Care·A I VinikG L Pittenger
Feb 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Youichirou OotsukaAndrej A Romanovsky
Jul 25, 2019·Frontiers in Physiology·Maxime FouchardBérengère Fromy
Feb 1, 2006·Vascular Medicine·John P Cooke, Janice M Marshall
Oct 1, 1996·European Journal of Oral Sciences·G D KostourosL Edwall
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·T KiviluotoE Kivilaakso

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