Mediation effect of hepatitis B and C on mortality

European Journal of Epidemiology
Yen-Tsung HuangChien-Jen Chen

Abstract

Hepatitis B (HBV) and C (HCV) viruses cause many liver diseases. To move beyond statistical interaction, we aimed to assess the coordinated effect of the two viruses on mortality using mediation analyses. A prospective cohort study of 3837 residents in Taiwan examined participants seropositive for hepatitis B, of which 181 subjects (4.7 %) were co-infected by HCV and 589 died during follow-up. Mediation analyses for cause-specific mortality were performed using Cox proportional hazards model. Follow-up HBV viral load was inversely correlated with baseline HCV viral load (r(2) = -0.074; P < 0.001). For HCV serum viral load increasing from 800 to 404,000 IU/mL (minimum to median) at baseline, the effect of HCV mediated through HBV viral load decreased the all-cause mortality with a hazard ratio (HR) of 0.89 (95 % confidence interval (CI) 0.85, 0.94; P < 0.001), and the effect independent of HBV viral load had an opposite HR of 1.25 (95 % CI 0.98, 1.60; P = 0.08). The protective mediation effects of HCV viral load through HBV DNA level were observed in mortality from causes specific to liver-related diseases and liver cancer, but not in that from non-liver-related diseases. Our findings suggest a suppressive effect of HCV on morta...Continue Reading

References

Aug 1, 1992·Japanese Journal of Medical Science & Biology·J S WuS Y Lin
Mar 1, 1992·Epidemiology·J M Robins, S Greenland
Jan 1, 1983·Journal of Medical Virology·K N TsiquayeR Williams
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y F Liaw
Mar 11, 1998·The Pediatric Infectious Disease Journal·S N LuC J Chen
Aug 2, 2000·Journal of Gastroenterology and Hepatology·C J ChenM W Yu
Nov 26, 2002·Journal of Hepatology·Christian G SchüttlerStephan Schaefer
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Chien-Jen ChenUNKNOWN REVEAL-HBV Study Group
Apr 15, 2006·International Journal of Medical Sciences·Zhihua Liu, Jinlin Hou
May 10, 2007·JAMA : the Journal of the American Medical Association·Thomas P GiordanoEric A Engels
Aug 7, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Uchenna H IloejeUNKNOWN Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus Study Group
Apr 1, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pantxika BellecaveDarius Moradpour
Sep 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mei-Hsuan LeeChien-Jen Chen
Nov 3, 2010·American Journal of Epidemiology·Tyler J Vanderweele, Stijn Vansteelandt
Jun 7, 2011·Epidemiology·Tyler J VanderWeele
Aug 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yen-Tsung HuangChien-Jen Chen
Feb 7, 2012·American Journal of Epidemiology·Tyler J VanderWeeleXihong Lin
Jul 20, 2012·The Journal of Infectious Diseases·Mei-Hsuan LeeUNKNOWN R.E.V.E.A.L.-HCV Study Group
Jul 30, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert L KruseFasiha Kanwal

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Citations

Mar 16, 2017·Epidemiology·Yen-Tsung Huang, Hwai-I Yang
Jul 31, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Danae BixlerUNKNOWN CHeCS Investigators

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