Mediation of beta-endorphin in exercise-induced improvement in insulin resistance in obese Zucker rats

Diabetes/metabolism Research and Reviews
C-F SuJ-T Cheng

Abstract

Aerobic exercise including treadmill running has long been used to successfully treat and/or prevent insulin resistance and type-2 diabetes. Increase of plasma beta-endorphin is observed with exercise. The present study was designed to clarify the role of endogenous beta-endorphin in exercise-induced improvement in insulin resistance. We used a moderate exercise program consisting of treadmill running at 20 m/min and 0% grade for 1 h/day, 7 days/week, for 8 weeks. Plasma glucose concentration was assessed by the glucose oxidase method. The enzyme-linked immunosorbent assay was performed to quantify the plasma level of beta-endorphin-like immunoreactivity (BER). The glucose disposal rate (GDR) was measured by the hyperinsulinemic euglycemic clamp technique. Changes of the insulin signaling in isolated soleus muscle were then detected by immunoprecipitation and immunoblotting. An increase of plasma BER in parallel with the reduction of plasma glucose was obtained in exercise-trained obese Zucker rats. Different from a marked reduction in sedentary obese rats, the value of insulin-stimulated GDR obtained from the exercised obese rats was reversed to near that of the sedentary lean group, eight weeks after the last period of exerci...Continue Reading

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Citations

Mar 29, 2006·European Journal of Applied Physiology·Shih-Pei ChangJuei-Tang Cheng
Jul 27, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Raj Kumar YadavSushil Chandra Mahapatra
Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Thing-Fong TzengI-Min Liu
May 22, 2013·Pharmacology & Therapeutics·Kai-Chun ChengAkio Inui
May 5, 2011·Endocrine Research·Dionízia Xavier ScomparinPaulo Cezar de Freitas Mathias
Mar 11, 2016·Advanced Biomedical Research·Atefeh Asadi RiziNooshin Naghsh
Jan 7, 2011·Neurological Research·Lori Burkow-Heikkinen
Nov 30, 2011·Experimental Gerontology·Hitoshi MurakamiStephane Walrand
Sep 16, 2006·Peptides·Richard J Bodnar, Gad E Klein
May 23, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jieyun YinJiande D Z Chen
Oct 6, 2009·Medical Hypotheses·Prajakta V BelsareMaithili Jog

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