Mediation of exogenous hydrogen sulfide in recovery of ischemic post-conditioning-induced cardioprotection via down-regulating oxidative stress and up-regulating PI3K/Akt/GSK-3β pathway in isolated aging rat hearts

Cell & Bioscience
Hongzhu LiChangqing Xu

Abstract

The physiological and pathological roles of hydrogen sulfide (H2S) in the regulation of cardiovascular functions have been recognized. Cystathionine gamma-lyase (CSE) is a major H2S-producing enzyme in cardiovascular system. Ischemic post-conditioning (PC) provides cadioprotection in young hearts but lost in the aging hearts. The involvement of H2S in the recovery of PC-induced cardioprotection in the aging hearts is unclear. In the present study, we demonstrated that ischemia/reperfusion (I/R) decreased H2S production rate and CSE expression, aggravated cardiomyocytes damage, apoptosis and myocardial infarct size, reduced cardiac function, increased the levels of Bcl-2, caspase-3 and caspase-9 mRNA, enhanced oxidative stress in isolated young and aging rat hearts. I/R also increased the release of cytochrome c and down-regulated the phosphorylation of PI3K, Akt and GSK-3β in the aging rat hearts. We further found that PC increased H2S production rate and CSE expressions, and protected young hearts from I/R-induced cardiomyocytes damage, all of which were disappeared in the aging hearts. Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and signif...Continue Reading

References

Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·D T Lucas, L I Szweda
Jan 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P H Chan
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rui Wang
Sep 19, 2003·Antioxidants & Redox Signaling·Rui Wang
Dec 20, 2003·Biochemical and Biophysical Research Communications·Bin GengChaoshu Tang
Jul 9, 2004·Clinical and Experimental Pharmacology & Physiology·Juliet M Taylor, Peter J Crack
Mar 21, 2006·Cardiovascular Research·Zhi-Qing Zhao, Jakob Vinten-Johansen
May 2, 2006·Journal of the American College of Surgeons·Paul R CrisostomoDaniel R Meldrum
Oct 5, 2006·Current Alzheimer Research·Kok Poh LohYi Zhun Zhu
Nov 15, 2006·Current Drug Targets·Wulf DrögeThomas Schmitt
Aug 4, 2007·Biochemical and Biophysical Research Communications·Wei-Hua ZhangChang-Qing Xu
Aug 4, 2007·Pflügers Archiv : European journal of physiology·Yeshi HuJin-Song Bian
Oct 20, 2007·Nature Reviews. Drug Discovery·Csaba Szabó
Nov 9, 2007·American Journal of Physiology. Cell Physiology·Ting-Ting PanJin-Song Bian
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dana L Miller, Mark B Roth
Apr 5, 2008·Journal of the American College of Cardiology·Karin PrzyklenkPeter Whittaker
Jul 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Qian Chen YongJin-Song Bian
Jan 30, 2009·Cardiovascular Research·Kerstin BoenglerGerd Heusch
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kunihiro SuzukiCsaba Szabo
Nov 26, 2011·Expert Review of Clinical Pharmacology·Edward G Lynn, Richard C Austin
Mar 2, 2013·Journal of the American Society of Nephrology : JASN·Eelke M BosHarry van Goor

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Citations

Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zengyong QiaoJingyu Yang
Sep 8, 2015·Experimental Gerontology·Jamila R SanchezRochelle Buffenstein
Jul 11, 2020·Reproduction in Domestic Animals = Zuchthygiene·Yi FangRongzhen Zhong
Apr 22, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eric R DeLeonKenneth R Olson
Jun 1, 2018·International Journal of Endocrinology·Simón Quetzalcóatl Rodríguez-LaraAlejandra Guillermina Miranda-Díaz
Oct 16, 2018·Molecular Medicine Reports·Zhengxin HuangXianping Huang
Mar 3, 2017·Oxidative Medicine and Cellular Longevity·Sashko Georgiev SpassovSimone Faller
Feb 10, 2020·Experimental Gerontology·Domenico LapennaEttore Porreca
Jun 3, 2021·International Journal of Molecular Sciences·Imran A ErtugrulMichiel E Erasmus

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Methods Mentioned

BETA
MDA
PCR

Software Mentioned

Bio
OriginPro
SPSS
Rad Quantity One
iCycler optical system

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