Mediation of immunity to intracellular infection (Toxoplasma and Besnoitia) within somatic cells.

Infection and Immunity
M Chinchilla, J K Frenkel

Abstract

Antigen-treated lymphocytes from immune hamsters specifically protected not only macrophages, but also cultured fibroblasts and kidney cells infected with Toxoplasma gondii or Besnoitia jellisoni. Macrophages were not necessary for the protection of fibroblasts and kidney cells. A mediator that inhibited the intracellular proliferation of these microbes was obtained from immune lymphocytes in contact with specific antigen. Again, macrophages were not necessary for the elaboration of this mediator or its activity in kidney cells or fibroblasts. The mediator was microbe and host specific, had a molecular weight between 4,000 and 5,000, was resistant to heating at 56 degrees C for 30 min, and was sensitive to chymotrypsin, but resistant to ribonuclease and deoxyribonuclease. A single injection of Besnoitia mediator afforded better protection to hamsters infected with Besnoitia than did antibody. Whereas antibody lysed extracellular organisms, the microbe-specific mediators conferred immunity not only on macrophages, but also on other cells of the body, apparently the first such demonstration.

References

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Citations

Jan 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·E U Canning
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·C F Nathan
Apr 5, 1984·The New England Journal of Medicine·H W MurrayR B Roberts
Jan 1, 1983·Medical Microbiology and Immunology·H Hof
Nov 1, 1979·Infection and Immunity·M E Rose, P Hesketh
Apr 1, 1986·Infection and Immunity·R E McCabe, J S Remington
Dec 1, 1984·Infection and Immunity·M Chinchilla, J K Frenkel
Apr 1, 1987·Infection and Immunity·L Reyes, J K Frenkel
Jul 1, 1988·Infection and Immunity·M E RoseD Wakelin
Oct 1, 1982·Infection and Immunity·J K Frenkel, D W Taylor

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