Abstract
We examined whether norepinephrine originating in the locus coeruleus mediates the micturition reflex in anesthetized cats. 6-Hydroxydopamine, a catecholamine neurotoxin, injected bilaterally into the locus coeruleus markedly decreased catecholamine fluorescence in the lesioned area and induced urinary retention after 72 to 84 hr. At this time, there was no or only slight contraction of the urinary bladder induced by its distension, while the contraction was noted before the treatment. However, phenylephrine, an alpha 1-receptor agonist, applied intrathecally in 6-hydroxydopamine-treated animals induced moderate bladder contraction. In sham-operated animals, the bladder contraction on its distension was inhibited by intrathecally applied prazosin, an alpha 1-receptor antagonist. Thus, in the micturition reflex, norepinephrine derived from the locus coeruleus acts on the alpha 1-adrenergic receptors in the sacral cord, and induces urinary bladder contraction via activation of the sacral parasympathetic preganglionic neurons.
References
Aug 31, 1979·Brain Research·A D LoewyR P Baker
Mar 28, 1975·Brain Research·Y OsumiS Takaori
Apr 11, 1975·Brain Research·W C De Groat
Sep 24, 1985·European Journal of Pharmacology·L T GironS G Crist-Orlando
Jul 9, 1986·Brain Research·M SasaS Takaori
Feb 1, 1988·The Journal of Urology·N YoshimuraS Takaori
Oct 1, 1988·The Journal of Urology·O NishizawaS Tsuchida
Jun 4, 1986·Brain Research·M ElamT H Svensson
Aug 22, 1986·The Journal of Comparative Neurology·G HolstegeE Dalm
Nov 22, 1974·Brain Research·M SasaS Takaori
Feb 25, 1982·Brain Research·S B McMahon, K Spillane
Jan 1, 1982·Clinical Neuropharmacology·W E Bradley, T Sundin
Jan 1, 1982·Progress in Brain Research·K N WestlundJ D Coulter
Mar 14, 1983·Brain Research·K N WestlundJ D Coulter
Sep 1, 1980·The Journal of Comparative Neurology·I NadelhaftC Morgan
Nov 1, 1955·Journal of Neurophysiology·P C TANG
Oct 1, 1964·The Journal of Comparative Neurology·M KURU, H YAMAMOTO
Apr 1, 1978·Neuroscience Letters·K SatohT Maeda
Citations
Mar 1, 1996·British Journal of Pharmacology·O IshizukaK Andersson
Jan 1, 1997·International Urogynecology Journal and Pelvic Floor Dysfunction·T C Chai, W D Steers
Apr 26, 2000·BJU International·K E Andersson
Feb 24, 2001·Japanese Journal of Pharmacology·H KontaniS Kimura
Jun 14, 2013·Journal of Psychopharmacology·Elemer Szabadi
Apr 28, 2001·British Journal of Pharmacology·R K ConleyA G Ramage
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·W C de Groat, N Yoshimura
Aug 11, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K B Thor
Feb 11, 2015·Biogerontology·Richard N Ranson, M Jill Saffrey
Mar 25, 2017·The Journal of Comparative Neurology·Anne M J VerstegenJoel C Geerling
Oct 15, 1994·Microscopy Research and Technique·M Sasa, N Yoshimura
Mar 1, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·N Yoshimura, W C de Groat
Jan 1, 1997·Neurourology and Urodynamics·O IshizukaK E Andersson
Mar 14, 2002·BJU International·J H BaeJ G Lee
Jun 18, 2004·The Journal of Urology·Karl B Thor, Craig Donatucci
Jul 30, 2010·American Journal of Physiology. Renal Physiology·Masaru YoshizumiMasahito Kawatani
May 3, 2000·BJU International·M S Jeong, J G Lee
Aug 19, 2003·British Journal of Pharmacology·Naoki YoshimuraSatoshi Seki
Sep 17, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Marco DellabellaGiovanni Muzzonigro
Sep 17, 2014·Nature Reviews. Urology·Qi-Xiang SongMargot S Damaser
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M Yoshiyama, W C De Groat
Feb 13, 2003·The Urologic Clinics of North America·Mike B Siroky
May 1, 1996·The Urologic Clinics of North America·T C Chai, W D Steers