Mediation of micturition reflex by central norepinephrine from the locus coeruleus in the cat

The Journal of Urology
N YoshimuraS Takaori

Abstract

We examined whether norepinephrine originating in the locus coeruleus mediates the micturition reflex in anesthetized cats. 6-Hydroxydopamine, a catecholamine neurotoxin, injected bilaterally into the locus coeruleus markedly decreased catecholamine fluorescence in the lesioned area and induced urinary retention after 72 to 84 hr. At this time, there was no or only slight contraction of the urinary bladder induced by its distension, while the contraction was noted before the treatment. However, phenylephrine, an alpha 1-receptor agonist, applied intrathecally in 6-hydroxydopamine-treated animals induced moderate bladder contraction. In sham-operated animals, the bladder contraction on its distension was inhibited by intrathecally applied prazosin, an alpha 1-receptor antagonist. Thus, in the micturition reflex, norepinephrine derived from the locus coeruleus acts on the alpha 1-adrenergic receptors in the sacral cord, and induces urinary bladder contraction via activation of the sacral parasympathetic preganglionic neurons.

References

Aug 31, 1979·Brain Research·A D LoewyR P Baker
Apr 11, 1975·Brain Research·W C De Groat
Oct 1, 1988·The Journal of Urology·O NishizawaS Tsuchida
Jan 1, 1982·Clinical Neuropharmacology·W E Bradley, T Sundin
Jan 1, 1982·Progress in Brain Research·K N WestlundJ D Coulter
Mar 14, 1983·Brain Research·K N WestlundJ D Coulter
Nov 1, 1955·Journal of Neurophysiology·P C TANG
Oct 1, 1964·The Journal of Comparative Neurology·M KURU, H YAMAMOTO

❮ Previous
Next ❯

Citations

Jan 1, 1997·International Urogynecology Journal and Pelvic Floor Dysfunction·T C Chai, W D Steers
Feb 24, 2001·Japanese Journal of Pharmacology·H KontaniS Kimura
Jun 14, 2013·Journal of Psychopharmacology·Elemer Szabadi
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·W C de Groat, N Yoshimura
Aug 11, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K B Thor
Feb 11, 2015·Biogerontology·Richard N Ranson, M Jill Saffrey
Mar 25, 2017·The Journal of Comparative Neurology·Anne M J VerstegenJoel C Geerling
Oct 15, 1994·Microscopy Research and Technique·M Sasa, N Yoshimura
Mar 1, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·N Yoshimura, W C de Groat
Jul 30, 2010·American Journal of Physiology. Renal Physiology·Masaru YoshizumiMasahito Kawatani
Sep 17, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Marco DellabellaGiovanni Muzzonigro
Sep 17, 2014·Nature Reviews. Urology·Qi-Xiang SongMargot S Damaser
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M Yoshiyama, W C De Groat
Feb 13, 2003·The Urologic Clinics of North America·Mike B Siroky
May 1, 1996·The Urologic Clinics of North America·T C Chai, W D Steers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.