Apr 1, 1976

Mediation of prostaglandin E2 in the biphasic response to ATP of the isolated tracheal muscle of guinea-pigs

The Journal of Pharmacy and Pharmacology
Y Kamikawa, Y Shimo

Abstract

ATP, at a dose higher than 0-1 mug m1(-1), showed a biphasic action consisting of an initial increase followed by a gradual decrease of muscle tension in the isolated tracheal strip-chains of guinea-pigs. The pattern of this biphasic response to ATP varied with the level of basal tone of the preparation at the moment of application of ATP. A smiliar biphasic action was obtained by prostaglandin (PG) E2 among the various active substances studied including acetylcholine, histamine, catecholamines and various types of PG. Indomethacin (0-1 mug m1(-1) and aspirin (30 mug m1(-1)) completely abolished the ATP-induced inhibitory response observed in the presence of histamine (10 muM). Polyphloretin phosphate (100 mug m1(-1)) also significantly depressed the inhibitory response to ATP or PGE2. It is concluded that the response to ATP of the preparation is mediated by PGE2 released via the stimulation of its biosynthesis.

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  • Citations16

Citations

Mentioned in this Paper

Histamine Measurement
Response to ATP
Depressed - Symptom
Cavia
Osmosin
Catecholamines Measurement
Trachea
Smooth Muscle
Zorprin
Prostaglandin E2 Measurement

About this Paper

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