Mediatophore and other presynaptic proteins. A cybernetic linking at the active zone

Journal of Physiology, Paris
Y Dunant, M Israël

Abstract

In rapidly transmitting synapses, the mediatophore, a protein located in the presynaptic membrane, seems to play a key role in the last step of transmitter release. Reconstituted either in proteoliposomes or in Xenopus oocytes, or transfected in particular cell lines, the mediatophore is able to release acetylcholine with characteristics which meet several typical features of transmitter release in natural synapses. Good correspondence between the two conditions was found for: i) the dependency of release upon calcium concentration; ii) the desensitisation of release by persistence of internal calcium; iii) the effect of several drugs; iv) the fleeting formation of a population of large intramembrane particles during the precise time of release; and v) the pulsatile or quantal nature of transmitter release. All these features therefore could well be ascribed to intrinsic properties of the mediatophore molecule. How is the mediatophore integrated in the whole presynaptic apparatus? To what extent is its function regulated by the other proteins of the active zone? These questions are far from being solved. We want nevertheless to propose here a general view in which characteristic presynaptic functions such as transmitter release...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C LevequeN Martin-Moutot
Jan 1, 1991·Molecular Carcinogenesis·M E FinbowJ B Findlay
Nov 1, 1990·The Journal of Cell Biology·L Thomas, H Betz
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M MandelN Nelson
Oct 1, 1989·Journal of Bioenergetics and Biomembranes·N Nelson
Aug 3, 1989·European Journal of Pharmacology·Y M Gaudry-TalarmainM Israël
Aug 1, 1987·Pflügers Archiv : European journal of physiology·M GanselF Dreyer
Apr 1, 1985·Scientific American·Y Dunant, M Israël
Oct 1, 1985·The Journal of Cell Biology·F Torri-TarelliB Ceccarelli
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M IsraëlR Manaranche
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D MullerY Dunant
Aug 1, 1969·The Journal of Physiology·B Katz, R Miledi
Sep 1, 1971·The Journal of Physiology·A J Harris, R Miledi
Jul 1, 1974·The Journal of General Physiology·M E Kriebel, C E Gross
Jul 1, 1980·Journal of Neurochemistry·D M MichaelsonI Angel
Apr 1, 1980·Physiological Reviews·B Ceccarelli, W P Hurlbut
Dec 1, 1994·Journal of Neuroscience Methods·V MizuhiraM Notoya
Jan 1, 1993·Progress in Brain Research·M Israël, Y Dunant
Nov 1, 1993·The European Journal of Neuroscience·A CavalliM Israël
May 1, 1994·Cell Biology International·Y Dunant
Jan 1, 1993·Cell·R B Kelly

❮ Previous
Next ❯

Citations

Apr 29, 1998·Molecular Neurobiology·M Israël, Y Dunant
Sep 1, 1996·Pflügers Archiv : European journal of physiology·Y DunantM Israël
Jan 27, 2005·The Anatomical Record. Part B, the New Anatomist·Robert B Silver, George D Pappas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.