PMID: 62774Dec 1, 1976

Mediator release from basophil granulocytes in chronic myelogenous leukemia

The Journal of Allergy and Clinical Immunology
R A ClarkA P Kaplan


Mediator release from the leukocytes of two patients with chronic myelogenous leukemia and basophilia was studied using rabbit antihuman IgE antibody. The release of histamine, slow reacting substance of anaphylaxis (SRS-A), platelet activating factor (PAF), chemotactic activity for neutrophils and eosinophils, and an inhibitor of eosinophil migration was observed. However, the release of SRS-A from the basophils of one patient and the release of chemotactic activity from both patients displayed unusual properties. During acceleration of the disease process, the basophils of one patient released maximal SRS-A activity at progressively lower concentrations of anti-IgE. Both patients released a high molecular weight factor (M.W. greater than 20,000) which enhanced the migration of neutrophils and eosinophils and a low molecular weight chemotactic factor (M.W. less than 500) which selectively attracted eosinophils. A double peak of eosinophil chemotactic activity was routinely observed for the low molecular weight factor; this was shown to represent the eosinophil chemotactic activity of histamine with relative inhibition of migration at the histamine peak. There was little release of the tetrapeptides, ECF-A, in these patients wh...Continue Reading


Dec 1, 1975·The Journal of Experimental Medicine·R A ClarkA P Kaplan
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E J Goetzl, K F Austen
Mar 1, 1971·The Journal of Experimental Medicine·A B KayK F Austen
Nov 1, 1974·The Journal of Experimental Medicine·R A LewisK F Austen
Feb 21, 1974·The New England Journal of Medicine·S I WassermanK F Austen
Mar 24, 1955·Annals of the New York Academy of Sciences·R S SPEIRS
Mar 1, 1976·Inflammation·B M CzarnetzkiL M Lichtenstein


Mar 1, 1981·The Journal of Clinical Investigation·L M McManusR N Pinckard
Mar 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J M Mencia-HuertaP Braquet
Dec 1, 1985·British Journal of Haematology·M A Lett-Brown, H S Juneja
Nov 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dorothea Dijkstra, Almut Meyer-Bahlburg
Feb 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S TerasakiM Unoura

Related Concepts

Cell-Free System
Chemotaxis, Leukocyte
Molecular Sieve Chromatography
Dose-Response Relationship, Immunologic
Histamine Release
Immunoglobulin E
Leukemia, Monocytic, Chronic

Related Feeds


Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.


Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.