PMID: 36872May 1, 1979

Mediator stage in the functioning of the autonomic nervous system in pre- and postnatal ontogeny and the importance of its study for clinical application

Arkhiv anatomii, gistologii i émbriologii
V N Shvalev, R A Stropus


In 1972 a new definition "mediatory stage" in the development of the vegetative nervous system during ontogenesis was introduced and it was stated that at the prenatal stage in the heart, along the course of magistral vessels, and into other organs begin to sprout up at first nervous truncs lacking in mediators, and then, beginning from 8--9 weeks (in man), the mediators appear at first in cholinergic and then in adrenergic plexus (V. N. Shvalev et al., 1972). In clinical embryonal mortality is especially great during the stage of premediatory development, that corresponds to the period of placentation. The beginning of the mediatory stage (the 3d month of prenatal life) is characterized by an intensive differentiation of the neural apparatus in the heart and its innervated structures. At first cholinergic and then adrenergic nerve plexus are formed, nevertheless, by the time of birth these plexus, especially adrenergic ones are not yet fully differentiated. During the first year of life there is noted a rather high rate of so called "sudden death". During the following 3--4 years there is a new intensive rise in differentiation of the cardiac cholinergic and adrenergic nerve plexus and by the 6--8th year of age the density of ...Continue Reading

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