PMID: 7372359Jan 1, 1980Paper

Mediators of immune complex-induced aggregation of polymorphonuclear neutrophils. I. C5a anaphylatoxin, neutrophil cationic proteins and their cleavage fragments

International Archives of Allergy and Applied Immunology
G CamussiG Segoloni

Abstract

This study reports the results of in vitro investigations on the aggregation of polymorphonuclear neutrophils (PMN) induced by the C5a anaphylatoxin complement component as well as the cationic proteins (CP), which are released by challenging PMN with immune complexes (IC). The carboxy-peptidase-derived des-Arg fragments of CP and C5a; CPi and C5ai, inactive in terms of anaphylactic and chemotactic activity, nevertheless showed a more potent ability to aggregate PMN than CP and C5a. The process of PMN aggregation required metabolic energy and divalent cations, Ca++ and Mg++. The microtubular system and the subplasmalemmal microfilaments appeared to be of critical importance. Electron microscopic studies on aggregates of PMN obtained on stimulation with CP, C5a, CPi and C5ai showed parallel tracts of variable length of cell membranes at the points where cells were in contact with each other.

Citations

Jul 1, 1982·British Journal of Pharmacology·A W Ford-Hutchinson
Feb 1, 1989·The American Review of Respiratory Disease·S W Chang, N F Voelkel
Nov 1, 1981·Scandinavian Journal of Haematology·F C CappioF Gavosto
Jul 31, 1980·The New England Journal of Medicine·G CamussiC Tetta
May 1, 2012·European Journal of Pharmacology·Raphael G FerreiraAndré Klein
Oct 1, 1986·Kidney International·G CamussiA Vercellone
Dec 1, 1983·Kidney International·A AmadoriM Ricci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.