PMID: 11328223May 1, 2001Paper

Medical abortion at 57 to 63 days' gestation with a lower dose of mifepristone and gemeprost. A randomized controlled trial

Acta Obstetricia Et Gynecologica Scandinavica
World Health Organization Task Force on Post-ovulatory Methods of Fertility Regulation

Abstract

To compare the abortifacient efficacy and side-effects of 200 mg and 600 mg of mifepristone, followed by gemeprost 1 mg vaginally, at 57 to 63 days' gestation. Double-blind, randomized controlled trial. Ten international centers. Eight hundred and ninety-six healthy women requesting medical abortion. Participants were randomly assigned to receive a single oral dose of mifepristone of either 200 mg or 600 mg followed in 48 h by gemeprost 1 mg vaginally. The allocation sequence was concealed by using a central pharmacy, and double masking was maintained throughout the study. Complete abortion rate was the principal outcome measure. We also evaluated the incidence of side-effects and time to abort. The complete abortion rate with the lower dose of mifepristone was similar to that with the higher dose (92.4% vs. 91.7%). The relative risk of failure to achieve a complete abortion with the 200 mg dose compared to 600 mg dose was 0.9 (95% CI 0.6-1.4). The timing of the abortion and the incidence of side-effects were comparable in both groups, with the exception of reported nausea at one-week follow-up which was reported more frequently by women in the higher-dose group. The 200 mg dose of mifepristone is equally as effective as the 60...Continue Reading

References

Aug 28, 1996·JAMA : the Journal of the American Medical Association·C BeggD F Stroup
May 1, 1998·The New England Journal of Medicine·I M SpitzA Robbins

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Citations

Nov 28, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Premila W AshokGillian M M Flett
Aug 19, 2007·The New England Journal of Medicine·Jasveer VirkJørn Olsen
Jun 9, 2016·The New England Journal of Medicine·Michael F Greene, Jeffrey M Drazen
Sep 27, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Helena von HertzenUNKNOWN WHO Research Group on Post-Ovulatory Methods for Fertility Regulation

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