Medical and dietary management of eosinophilic esophagitis

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Quan M Nhu, Seema S Aceves

Abstract

Eosinophilic esophagitis (EoE) is a disease of chronic, allergen-driven, T-helper 2 (Th2) immune-mediated inflammation that progresses to fibrostenosis of the esophagus if left untreated. There are currently no Food and Drug Administration (FDA)-approved drugs for the treatment of EoE. This review focuses on the medical and dietary management of EoE. Manuscripts on EoE treatments were identified on PubMed. Original research, randomized control trials, retrospective studies, meta-analyses, case series, and on occasions, case reports of high relevance, were selected and reviewed. Current treatment strategies available to EoE patients center on monotherapy or combination therapy with dietary modification to exclude antigenic stimulation and topical corticosteroids to control Th2-mediated tissue inflammation and pathologic remodeling. Dilation as a rescue therapy for the narrowed, fibrostenotic, symptomatic esophagus can potentially be avoided with optimal medical and elimination diet therapies. The molecular mechanisms underlying EoE pathogenesis are being unraveled, from which targeted therapies can be developed and evaluated in preclinical and clinical studies. Current clinical research efforts focus on optimization of topical c...Continue Reading

Citations

Feb 2, 2019·Current Treatment Options in Gastroenterology·Quan M Nhu, Fouad J Moawad
Dec 14, 2019·BMJ Case Reports·Lybil Briscia Mendoza AlvarezSarah Glover
Oct 27, 2018·Frontiers in Medicine·Elisa Gomez TorrijosJoan Bartra
Sep 20, 2019·Scandinavian Journal of Gastroenterology·Tommaso AlterioValerio Nobili
May 1, 2020·Clinical and Translational Gastroenterology·Quan M NhuSeema S Aceves
Jan 9, 2020·The Journal of Allergy and Clinical Immunology·Nirmala P Gonsalves, Seema S Aceves
Feb 25, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jonathan M Spergel
Jun 29, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S DellonUNKNOWN ORBIT2/SHP621-302 Investigators
Oct 30, 2020·Pediatrics·Elizabeth Munoz-OsoresJ C Gana

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