Medical and surgical treatment for ocular myasthenia

The Cochrane Database of Systematic Reviews
Michael Benatar, Henry J Kaminski

Abstract

Approximately 50% of people with myasthenia gravis present initially with purely ocular symptoms, so called ocular myasthenia and between 50 to 60% of these people will progress to develop generalized disease. The vast majority will do so within the first one to two years. There is controversy surrounding the appropriate management of patients with ocular myasthenia. To perform a systematic review of the literature relevant to the treatment of ocular myasthenia and to answer three specific questions. Are there any medical or surgical treatments that have an impact on the risk of progression from ocular to generalized myasthenia gravis? Are there any medical or surgical treatments that improve symptoms of diplopia or ptosis in ocular myasthenia? What is the frequency of side effects associated with treatments used in people with ocular myasthenia? We searched the Cochrane Neuromuscular Disease Group Trials Register (searched December 2004), MEDLINE (1996 to 2004) and EMBASE (1980 to 2004) for randomized controlled trials as well as case-control and cohort studies. The titles and abstracts of all articles were read by both authors and the full text of all articles that were of possible relevance was reviewed in full. The referenc...Continue Reading

Citations

Jul 6, 2014·BMC Neurology·Shigeaki SuzukiKimiaki Utsugisawa
Oct 20, 2009·Revue neurologique·I Pénisson-Besnier
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Michael Benatar, Henry Kaminski
Oct 14, 2014·The Cochrane Database of Systematic Reviews·Man Mohan MehndirattaThierry Kuntzer
Apr 23, 2005·The Cochrane Database of Systematic Reviews·C Schneider-GoldR R Hohlfeld

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