Medical application of herpes simplex virus

Journal of Dermatological Science
Daisuke Watanabe

Abstract

Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are important human pathogens that cause a variety of diseases from mild skin diseases such as herpes labialis and herpes genitalis to life-threatening diseases such as herpes encephalitis and neonatal herpes. A number of studies have elucidated the roles of this virus in viral replication and pathogenicity, the regulation of gene expression, interaction with the host cell and immune evasion from the host system. This research has allowed the development of potential therapeutic agents and vectors for human diseases. This review focuses on the basic functions and roles of HSV gene products and reviews the current knowledge of medical applications of genetically engineered HSV mutants using different strategies. These major HSV-derived vectors include: (i) amplicons for gene delivery vectors; (ii) replication-defective HSV recombinants for vaccine vectors; (iii) replication-attenuated HSV recombinants for oncolytic virotherapy.

References

Jul 1, 1988·The Journal of General Virology·D J McGeochP Taylor
Jan 1, 1995·Biochimie·D Bataille, A L Epstein
Jan 13, 2004·Reviews in Medical Virology·Yukihiro Nishiyama
Feb 22, 2005·The Journal of General Virology·Tetsuo KoshizukaYukihiro Nishiyama
Jul 19, 2005·The Journal of Gene Medicine·J J Davis, B Fang
Oct 19, 2005·Gene Therapy·Alberto L Epstein
Jun 22, 2006·Current Gene Therapy·Khalid Shah, Xandra O Breakefield
Jun 22, 2006·Current Gene Therapy·Kathlyn SantosStephen Dewhurst
Jul 25, 2006·Microbes and Infection·Isamu Mori, Yukihiro Nishiyama
Aug 23, 2006·Acta Oto-laryngologica·Yasushi FujimotoYukihiro Nishiyama
Oct 3, 2006·International Journal of Radiation Oncology, Biology, Physics·Sunil J AdvaniRalph R Weichselbaum
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer C C HuR Charles Coombes
Aug 2, 2007·Expert Opinion on Biological Therapy·Delphine CuchetAlberto L Epstein
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Tomoki Todo
Jan 30, 2008·Journal of Dermatological Science·Daisuke WatanabeYukihiro Nishiyama
May 24, 2008·Human Vaccines·Peggy MarconiRoberto Manservigi
Oct 9, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Joseph C Glorioso, David J Fink

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Citations

Nov 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Rafaela ArgnaniRuben Hernandez-Alcoceba
Jul 24, 2013·Journal of Biomedical Materials Research. Part a·Deepa MishraAnshu B Mathur
Dec 30, 2017·Human Gene Therapy·Ding WeiHuijie Bian
Apr 18, 2014·Periodontology 2000·David HerreraMariano Sanz
Sep 4, 2019·Cancer Gene Therapy·Shinichi EsakiHiroshi Kimura

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