Medical applications and toxicities of gallium compounds.

International Journal of Environmental Research and Public Health
Christopher R Chitambar

Abstract

Over the past two to three decades, gallium compounds have gained importance in the fields of medicine and electronics. In clinical medicine, radioactive gallium and stable gallium nitrate are used as diagnostic and therapeutic agents in cancer and disorders of calcium and bone metabolism. In addition, gallium compounds have displayed anti-inflammatory and immunosuppressive activity in animal models of human disease while more recent studies have shown that gallium compounds may function as antimicrobial agents against certain pathogens. In a totally different realm, the chemical properties of gallium arsenide have led to its use in the semiconductor industry. Gallium compounds, whether used medically or in the electronics field, have toxicities. Patients receiving gallium nitrate for the treatment of various diseases may benefit from such therapy, but knowledge of the therapeutic index of this drug is necessary to avoid clinical toxicities. Animals exposed to gallium arsenide display toxicities in certain organ systems suggesting that environmental risks may exist for individuals exposed to this compound in the workplace. Although the arsenic moiety of gallium arsenide appears to be mainly responsible for its pulmonary toxicit...Continue Reading

References

Nov 1, 1979·Cancer·I H KrakoffR S Goldberg
Jul 1, 1992·Journal of Neuroimmunology·C WhitacreN Gerber
Aug 1, 1991·Toxicology and Applied Pharmacology·L A BurnsA E Munson
Aug 1, 1991·Toxicology and Applied Pharmacology·E E SikorskiA E Munson
Aug 1, 1991·Toxicology and Applied Pharmacology·E E SikorskiA E Munson
Aug 11, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R P WarrellG Heller
Nov 6, 1991·Journal of the National Cancer Institute·P A Seligman, E D Crawford
Nov 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·E E SikorskiA E Munson
Jul 1, 1987·American Industrial Hygiene Association Journal·D R WebbD E Carter
Oct 1, 1986·American Journal of Clinical Oncology·P DeSimoneA A Bartolucci
Feb 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R P WarrellR S Bockman
Jun 1, 1974·The Tohoku Journal of Experimental Medicine·M Oikawa
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M M Hart, R H Adamson
Jan 1, 1981·International Journal of Nuclear Medicine and Biology·R G Sephton, A W Harris
Jan 18, 1983·Biochemistry·W R Harris, V L Pecoraro
Oct 1, 1984·Toxicology and Applied Pharmacology·D R WebbD E Carter
Jan 1, 1981·International Journal of Nuclear Medicine and Biology·G S Johnston
Jan 1, 1981·International Journal of Nuclear Medicine and Biology·S R VallabhajosulaW Wolf
Nov 1, 1980·Cancer·D P KelsenC Young
Nov 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L H EinhornP J Loehrer
Feb 1, 1995·The Journal of Clinical Endocrinology and Metabolism·R S BockmanD Levenson
Feb 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S C KingL R Prosnitz
Dec 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R P WarrellR T Heelan
Nov 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M T ColominaJ Corbella
Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P T GuidonR S Bockman
Feb 1, 1993·European Journal of Nuclear Medicine·D SandrockR D Neumann
Apr 1, 1996·Annals of Hematology·J A van AmsterdamE K Pauwels
Jul 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M OmuraN Ishinishi
Dec 1, 1996·Toxicology and Applied Pharmacology·C B Hartmann, K L McCoy
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E SalloumD L Cooper

❮ Previous
Next ❯

Citations

Jun 12, 2012·Journal of Materials Science. Materials in Medicine·A W WrenM R Towler
Aug 31, 2013·Biological Trace Element Research·Gabriela GârbanCarmen Mitar
Jul 26, 2011·Journal of Veterinary Internal Medicine·M-E FecteauR W Sweeney
Jul 25, 2012·Antimicrobial Agents and Chemotherapy·Louis de LéséleucWangxue Chen
Oct 1, 2010·Therapeutic Advances in Endocrinology and Metabolism·Richard Carroll, Glenn Matfin
Jul 25, 2013·Critical Reviews in Oncogenesis·Kristina VanderWallAlan Lichtenstein
Jul 18, 2012·Future Medicinal Chemistry·Christopher R Chitambar
Apr 26, 2014·Future Microbiology·Fabrizia MinandriPaolo Visca
Feb 20, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ahmed SalemNihal Mostafa
Jul 24, 2013·Current Opinion in Pharmacology·Andrew B KelsonVu Truong-Le
Jun 20, 2012·Drug Discovery Today·E VerronJ C Scimeca
Dec 18, 2015·Journal of Materials Science. Materials in Medicine·Ehsan ZeimaranMark R Towler
Aug 1, 2012·Materials Science & Engineering. C, Materials for Biological Applications·Mirco FranchiniLedi Menabue
Oct 25, 2011·Acta Biomaterialia·Scott A JewettAlbena Ivanisevic
Nov 6, 2014·The Journal of Investigative Dermatology·Xuesong WuSam T Hwang
Nov 26, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Liqiang YanZhengjian Qi
Jun 2, 2011·Case Reports in Medicine·Paul H Goodley, Moshe Rogosnitzky
Nov 25, 2014·Journal of Medical Microbiology·Jon L Hobman, Lisa C Crossman
Apr 16, 2014·Journal of Veterinary Pharmacology and Therapeutics·F SampieriD L Hamilton
Sep 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Eman Kandil, Nahed Abdel Aziz
May 28, 2013·Critical Reviews in Toxicology·Ernst M BomhardSamuel M Cohen
May 16, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ingo J DielAda Braun
Apr 29, 2015·Frontiers in Microbiology·Adrián Rangel-VegaRodolfo García-Contreras
Mar 25, 2014·International Immunopharmacology·Jae-Hyeog ChoiYoung-Jae Kim
Jun 26, 2012·Regulatory Toxicology and Pharmacology : RTP·Ernst M BomhardGary M Williams
Nov 11, 2014·The Saudi Dental Journal·Argyro NtasiSpiros Zinelis
May 8, 2016·Biochimica Et Biophysica Acta·Christopher R Chitambar
Jun 18, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Katja Dralle MjosChris Orvig
Oct 6, 2016·Journal of Materials Science. Materials in Medicine·Mario KurtjakDanilo Suvorov
Jul 6, 2016·Environmental Pollution·C M MottaB Avallone
Feb 11, 2015·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Prinessa Chellan, Peter J Sadler
Jan 13, 2017·Journal of Tissue Engineering and Regenerative Medicine·Ivana Strazic GeljicJean-Claude Scimeca
Mar 29, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Eman I KandilOla Ms Khedr
Sep 30, 2017·Journal of Biomedical Materials Research. Part a·A BallardiniS Sprio
Aug 8, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Hyo Jung JangCheal Kim
Nov 2, 2016·Antimicrobial Agents and Chemotherapy·Federica RunciPaolo Visca

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
xenografts

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

Critical Reviews in Oncology/hematology
Philippe ColleryBernard Desoize
Current Opinion in Oncology
Christopher R Chitambar
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Clotilde MullerBernadette Faller
© 2021 Meta ULC. All rights reserved