Medical applications of macrocyclic polyamines

Current Medicinal Chemistry
Feng LiangChengtai Wu

Abstract

Macrocyclic polyamines comprise a special group of heterocycles that bind different guests. Over the past decade, medical interest has focused on macrocyclic polyamines owning to their chemical and biological properties. The discovery and development of the bicyclam AMD3100 highlighted the clinical potential of such compounds in AIDS, cancer and stem-cell mobilization. Many macrocyclic polyamines and their transition metal complexes had the cytotoxic activities to tumors through binding DNA, cleaving DNA, crosslinking DNA, or depleting the endogenous ATP levels of the tumor cells. Furthermore, macrocyclic polyamines also could be labeled with metal ionic radii and have applications in cancer radioimmunotherapy and in vivo magnetic resonance imaging (MRI). The current rational design, and medical applications of macrocyclic polyamines will be reviewed in this manuscript.

Citations

May 22, 2007·Amino Acids·R MontañezM A Medina
Apr 28, 2007·Nature Reviews. Drug Discovery·Robert A Casero, Laurence J Marton
Jan 4, 2013·Acta Crystallographica. Section E, Structure Reports Online·Vieri FusiPatrizia Rossi
Dec 18, 2012·Chemical Biology & Drug Design·Carla CruzJoão A Queiroz
May 4, 2015·Bioorganic & Medicinal Chemistry·Chiara MarchettiAndrea Milelli
Jan 4, 2017·Bioorganic Chemistry·Mansi VermaVipin K Garg
Jun 11, 2015·Organic & Biomolecular Chemistry·Oleksandr L KobzarValery P Kukhar
Jan 30, 2007·Chemistry & Biodiversity·Xiao-Qin XiongXiao-Ping Cao
Feb 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eleonora MacediVieri Fusi
Jun 27, 2015·Journal of Inorganic Biochemistry·Valeria LanzaGraziella Vecchio
May 19, 2012·Journal of the American Chemical Society·Mario InclánEnrique García-España

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