Medical benefits of using natural compounds and their derivatives having multiple pharmacological actions

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
I Kimura

Abstract

The multiple pharmacological actions of a unique compound are a prerequisite for classifying drugs as highly efficacious, because the multiple pharmacological actions offer the possibility of treating various symptoms of chronic diseases as described below. 1) Sustained hyperglycemia induces macrovascular and microvascular complications in type 2 diabetes mellitus. Antihyperglycemic medication and the control of postprandial hyperglycemia are essentially important for normalizing plasma glucose level. Gymnemic acid IV isolated from Gymnema sylvestre (Asclepiadaceae) leaves has antisweet, antihyperglycemic, glucose uptake inhibitory, and gut glycosidase inhibitory effects. Most of these pharmacological effects may synergistically contribute to alleviating type 2 diabetes-related symptoms. 2) Diabetic skeletal and vascular smooth muscles are hypersensitive to chemical transmitters, cytokines and autacoids. The sensitivity of neuromuscular synapses is enhanced in diabetes, which seems to be closely associated with neuropathy as one of the diabetic complications. beta-Eudesmol found in Atractylodes lancea rhizome has a desensitizing channel blocking action to nicotinic acetylcholine receptors, anti-angiogenic action in vascular end...Continue Reading

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Citations

Oct 3, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Yi LiuGenquan Qiu
Nov 14, 2008·American Journal of Health Promotion : AJHP·Larry A TuckerTroy B Adams
Mar 2, 2010·Bioorganic & Medicinal Chemistry·Thomas M EhrmanPeter J Hylands
Oct 13, 2009·Toxicology·J J BurnsKevin Spelman
Nov 26, 2010·Phytotherapy Research : PTR·K SpelmanE J Williams
Dec 1, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Mi Young SongYong-Ki Park
Jul 30, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giovanni Di FabioArmando Zarrelli
Aug 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nafiz Öncü CanÖzgür Devrim Can
Sep 13, 2018·Current Neuropharmacology·Muneeb U RehmanRehan Khan
Dec 15, 2007·Molecular and Cellular Biochemistry·Sumio IshijimaYusuke Izutani
Jul 30, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jindong ZhaoZhaohui Fang

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