Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders

Journal of Child Neurology
Stephanie LibzonLubov Blumkin

Abstract

A complex motor disorder is a combination of various types of abnormal movements that are associated with impaired quality of life (QOL). Current therapeutic options are limited. We studied the efficacy, safety, and tolerability of medical cannabis in children with complex motor disorder. This pilot study was approved by the institutional ethics committee. Two products of cannabidiol (CBD) enriched 5% oil formulation of cannabis were compared: one with 0.25% δ-9-tetrahydrocannabinol (THC) 20:1 group, the other with 0.83% THC 6:1 group. Patients aged 1 to 17 years (n = 25) with complex motor disorder were enrolled. The assigned medication was administered for 5 months. Significant improvement in spasticity and dystonia, sleep difficulties, pain severity, and QOL was observed in the total study cohort, regardless of treatment assignment. Adverse effects were rare and included worsening of seizures in 2 patients, behavioral changes in 2 and somnolence in 1.

References

Jul 10, 1999·Developmental Medicine and Child Neurology·M J BarryA L Albright
Aug 20, 2005·Developmental Medicine and Child Neurology·Martin BaxUNKNOWN Executive Committee for the Definition of Cerebral Palsy
Jul 25, 2009·Developmental Medicine and Child Neurology·Elizabeth WatersSaroj Saigal
Jan 11, 2014·Journal of Neurosurgery. Pediatrics·Francesco Motta, Clara E Antonello
Jun 11, 2014·Current Opinion in Pediatrics·Scott E Hadland, Sion K Harris
Feb 5, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Benzi KlugerJoseph Jankovic
Feb 5, 2015·Journal of Developmental and Behavioral Pediatrics : JDBP·Scott E HadlandSion K Harris
Jun 11, 2015·Journal of Child Neurology·Anup D Patel
Aug 15, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Vincenzo Di Marzo, Fabiana Piscitelli
Aug 15, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Barbara S Koppel
Mar 1, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Daniel E LumsdenJean-Pierre Lin
May 4, 2016·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·George Sam Wang
Jun 16, 2016·Lancet Neurology·Anne KoyLars Timmermann
Aug 11, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Michaela KuhlenGisela Janßen
Dec 3, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·A I BuizerR J Vermeulen
Feb 22, 2017·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Daniel E LumsdenJean-Pierre Lin
May 26, 2017·The New England Journal of Medicine·Samuel F Berkovic
May 26, 2017·The New England Journal of Medicine·Orrin DevinskyUNKNOWN Cannabidiol in Dravet Syndrome Study Group
Jun 18, 2017·Paediatric Drugs·Quyen N Luc, Jyes Querubin

❮ Previous
Next ❯

Citations

Jun 3, 2018·British Journal of Clinical Pharmacology·Lihi Bar-Lev SchleiderVictor Novack
Apr 18, 2019·Developmental Medicine and Child Neurology·Finbar O'callaghan
Dec 12, 2019·Journal of Child Neurology·Jenny L WilsonPennylope Hogarth
Mar 4, 2020·Substance Use & Misuse·Victoria ZeylRachel S Wightman
Dec 14, 2019·Current Opinion in Pediatrics·Lauren SingerRuth L Milanaik
Mar 25, 2020·Journal of Ethnobiology and Ethnomedicine·Madalina PetranMarilena Gilca
Jan 27, 2019·Developmental Medicine and Child Neurology·Suzanne NielsenWayne Hall
Jun 18, 2020·Adolescent Health, Medicine and Therapeutics·Julia J WooZainab Samaan
Apr 30, 2020·Paediatrics & Child Health·Colleen PawliukHarold Hal Siden
Jul 14, 2021·Expert Opinion on Drug Delivery·Ízola Morais de Medeiros RamalhoEryvaldo Socrates Tabosa do Egito
Jul 27, 2021·European Journal of Pediatrics·Kathrin ZürcherLukas Fenner

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

Excel
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seizure : the Journal of the British Epilepsy Association
Michal TzadokBruria Ben-Zeev
Neurología : publicación oficial de la Sociedad Española de Neurología
L Lorente FernándezB Casanova-Estruch
© 2022 Meta ULC. All rights reserved