Medical comorbidity in bipolar disorder: relationship between illnesses of the endocrine/metabolic system and treatment outcome.

Bipolar Disorders
David E KempJoseph R Calabrese

Abstract

The present study examined the relationship between medical burden in bipolar disorder and several indicators of illness severity and outcome. It was hypothesized that illnesses of the endocrine/metabolic system would be associated with greater psychiatric symptom burden and would impact the response to treatment with lithium and valproate. Data were analyzed from two studies evaluating lithium and valproate for rapid-cycling presentations of bipolar I and II disorder. General medical comorbidity was assessed by the Cumulative Illness Rating Scale (CIRS). Descriptive statistics and logistic regression analyses were conducted to explore the relationships between medical burden, body mass index (BMI), substance use disorder status, and depressive symptom severity. Of 225 patients enrolled, 41.8% had a recent substance use disorder, 50.7% were male, and 69.8% had bipolar I disorder. The mean age of the sample was 36.8 (SD = 10.8) years old. The mean number of comorbid medical disorders per patient was 2.5 (SD = 2.5), and the mean CIRS total score was 4.3 (SD = 3.1). A significant positive correlation was observed between baseline depression severity and the number of organ systems affected by medical illness (p = 0.04). Illnesses ...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Nov 21, 1990·JAMA : the Journal of the American Medical Association·D A RegierF K Goodwin
May 1, 1968·Journal of the American Geriatrics Society·B S LinnL Gurel
Jan 1, 1993·Journal of the American Geriatrics Society·Y ConwellE D Caine
May 19, 2000·The Journal of Clinical Psychiatry·J L ElmslieS E Romans
Sep 26, 2001·Archives of General Psychiatry·U OsbyP Sparén
Apr 3, 2002·The Journal of Clinical Psychiatry·Susan L McElroyRobert M Post
Jun 14, 2002·Journal of Affective Disorders·F AngstJ Angst
Jun 29, 2002·The Journal of Clinical Psychiatry·Andrea FagioliniDavid J Kupfer
Dec 31, 2002·The American Journal of Psychiatry·Andrea FagioliniEllen Frank
May 3, 2003·Journal of Clinical Epidemiology·Vincent de GrootLex M Bouter
Sep 16, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Martina RuzickovaMartin Alda
Nov 26, 2003·The American Journal of Psychiatry·Dan V IosifescuMaurizio Fava
Nov 6, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ritesh MistryUNKNOWN UPBEAT Collaborative Group
Nov 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John BeyerK Ranga R Krishnan
May 10, 2005·Journal of Clinical Epidemiology·C HudonA Vanasse
Dec 13, 2005·Sleep·Amir SharafkhanehMax Hirshkowitz
Jul 5, 2006·Archives of General Psychiatry·Gregory E SimonRonald C Kessler
Jul 28, 2006·Psychiatric Services : a Journal of the American Psychiatric Association·Roger S McIntyreSidney H Kennedy
Nov 30, 2006·Archives of Internal Medicine·Simon GilbodyAlex J Sutton
Mar 6, 2007·General Hospital Psychiatry·John W WilliamsAllen Dietrich
May 9, 2007·Archives of General Psychiatry·Kathleen R MerikangasRonald C Kessler
Oct 6, 2007·The Journal of Clinical Psychiatry·Roger S McIntyreSidney H Kennedy
Oct 19, 2007·PLoS Biology·Jason M WilliamsAurelio Galli
Dec 7, 2007·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Roger S McIntyreSidney H Kennedy
Dec 14, 2007·Journal of Psychiatric Research·Isabella SorecaDavid J Kupfer
Jan 18, 2008·Neuroscience and Biobehavioral Reviews·Flavio KapczinskiRobert M Post
Feb 1, 2008·Journal of Affective Disorders·Giuseppe MainaFilippo Bogetto
Mar 18, 2008·Journal of Clinical Psychopharmacology·Andrea FagioliniDavid J Kupfer
Jul 1, 2008·Psychiatric Services : a Journal of the American Psychiatric Association·Amy M KilbourneMark S Bauer
Jul 4, 2008·Biological Psychiatry·Lucile CapuronViola Vaccarino
Sep 25, 2008·Journal of the American Geriatrics Society·Fabio SalviPaolo Dessì-Fulgheri
Oct 22, 2008·Journal of Affective Disorders·Paul A PirragliaMark S Bauer
Nov 4, 2008·Pharmacology, Biochemistry, and Behavior·Candy W Y LawRoger S McIntyre
Dec 23, 2008·Journal of Affective Disorders·David E KempJoseph R Calabrese
Jan 30, 2009·Psychiatric Services : a Journal of the American Psychiatric Association·Babak Roshanaei-Moghaddam, Wayne Katon
Feb 5, 2009·Current Diabetes Reports·Roger S McIntyreBenjamin I Goldstein

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Citations

Apr 12, 2011·Advances in Therapy·Ameena T AhmedRoger S McIntyre
Oct 12, 2013·Journal of Child and Adolescent Psychopharmacology·David E KempKiki Chang
Apr 3, 2012·Journal of Geriatric Psychiatry and Neurology·Ariel GildengersMartha Sajatovic
Jun 21, 2012·BMC Health Services Research·Athanassios DouzenisLefteris Lykouras
Feb 13, 2016·Journal of Affective Disorders·Rodrigo B MansurElisa Brietzke
Jan 10, 2016·Journal of Psychiatric Research·Rodrigo B MansurElisa Brietzke
Jan 3, 2016·Journal of Psychiatric Research·Isabelle E BauerThomas D Meyer
Jun 27, 2015·Acta Psychiatrica Scandinavica·S L McElroyR C Shelton
Jul 30, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·David E KempEduard Vieta
Aug 27, 2015·Bipolar Disorders·Cynthia V Calkin, Martin Alda
May 1, 2012·Psychiatric Annals·David E Kemp, Jinbo Fan
Oct 10, 2015·Journal of Affective Disorders·Emily E BernsteinLouisa G Sylvia
Sep 1, 2015·General Hospital Psychiatry·John LallyFiona Gaughran
Jan 5, 2013·Bipolar Disorders·Benjamin I GoldsteinCarlos Blanco
Aug 17, 2011·Bipolar Disorders·Benjamin I GoldsteinCarlos Blanco
Aug 6, 2013·Bipolar Disorders·Ameena T AhmedRoger S McIntyre
Mar 8, 2013·Acta Psychiatrica Scandinavica·D E KempUNKNOWN LiTMUS Study Group
Mar 4, 2014·Bipolar Disorders·Sergey MosolovJules Angst
Feb 15, 2014·Neuroscience Letters·Márcio Gerhardt Soeiro-de-SouzaAntônio Lúcio Teixeira
May 15, 2015·International Journal of Psychiatry in Clinical Practice·Mohammad AhmadpanahSerge Brand
Oct 16, 2014·Health Care for Women International·Laura J MillerJudy A Greene
Sep 12, 2015·The Lancet. Psychiatry·David J KupferFiona C Ritchey
Jan 13, 2015·Neuroscience and Biobehavioral Reviews·Rodrigo B MansurRoger S McIntyre
May 21, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adrian L Lopresti, Peter D Drummond
Dec 26, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rodrigo B MansurElisa Brietzke
Feb 19, 2014·Psychiatry Research·Lauren M WeinstockIvan W Miller
Jun 19, 2013·Journal of Psychiatric Research·Klaus MunkholmMaj Vinberg
Dec 24, 2014·Journal of Affective Disorders·Shefali MillerTerence A Ketter
Jun 9, 2014·European Psychiatry : the Journal of the Association of European Psychiatrists·C BoudebesseB Etain
Sep 1, 2013·Revista colombiana de psiquiatría·Carlos López JaramilloJulieta Osorio Zuluaga
Jun 10, 2016·Journal of Psychiatric Research·Rodrigo B MansurElisa Brietzke
Aug 21, 2016·Bipolar Disorders·Kyle J BurghardtVicki L Ellingrod
Jan 21, 2017·Journal of Affective Disorders·Ana SayuriYamagataRoger S McIntyre

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Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.