Medical costs associated with chronic kidney disease progression in an Asian population with type 2 diabetes mellitus

Nephrology
Serena LowChee F Sum

Abstract

We aim to examine difference in incremental direct medical costs between non-progressive and progressive chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM) in Singapore. This was a prospective study on 676 patients with T2DM attending a diabetes centre in a regional hospital. Annual direct medical costs were extracted from the administrative database. Ordinary least squares regression was used to estimate contribution of CKD progression to annual costs, adjusting for demographics and baseline clinical covariates. Over mean follow-up period of 2.8 ± 0.4 years, 266 (39.3%) had CKD progression. The excess total follow-up medical costs from baseline was S$4243 higher in progressors compared to non-progressors (P = 0.002). The mean cost differential between the two groups increased from S$2799 in Stages G1-G2 to S$11180 in Stage G4. Inpatient cost accounted for 63.4% of total cost of progression. When stratified by glomerular filtration rate stages, the respective total mean annual costs at stages glomerular filtration rate Stages G3a-G3b and G4 were S$3290 (132%; P = 0.001) and S$4416 (135%; P = 0.011) higher post-progression. Chronic kidney disease progression in T2DM is associated with high medical costs. The cost of...Continue Reading

References

Sep 24, 1999·Archives of Internal Medicine·J B BrownA W Bakst
Apr 15, 2004·European Journal of Public Health·Irmgard Schmitt-KoopmannThomas D Szucs
Feb 3, 2005·Health Economics·Andrew BriggsSimon Thompson
Apr 25, 2006·Journal of Diabetes and Its Complications·Andrea MorsanuttoLorenzo Giovanni Mantovani
Jan 1, 2008·The Spine Journal : Official Journal of the North American Spine Society·Simon DagenaisScott Haldeman
Mar 1, 2008·Diabetes Care·UNKNOWN American Diabetes Association
Feb 24, 2009·Applied Health Economics and Health Policy·Elise M PelletierMichael E Minshall
May 21, 2009·BMC Pulmonary Medicine·Katayoun BahadoriJ Mark FitzGerald
Oct 26, 2011·Diabetes Care·Gregory A NicholsHelen Lau
Nov 9, 2011·PloS One·Mehdi JavanbakhtAboozar Sadeghi
Jun 28, 2012·World Journal of Diabetes·Ambady RamachandranArun Nanditha
Nov 12, 2013·Journal of Diabetes and Its Complications·Suma VupputuriGregory A Nichols
May 13, 2014·Diabetes Research and Clinical Practice·Charmaine S NgYu Ko
Aug 15, 2014·Indian Journal of Nephrology·K SatyavaniV Viswanathan
Mar 20, 2015·PharmacoEconomics·Till SeuringMarc Suhrcke
May 4, 2015·Diabetes Research and Clinical Practice·Mukoso N OziehLeonard E Egede
Jul 26, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michelle J PenaHiddo J Lambers Heerspink

❮ Previous
Next ❯

Citations

Jun 3, 2021·BMC Health Services Research·Carlos EscobarManuel Botana

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.