Medical dissolution therapy for the treatment of uric acid nephrolithiasis.

World Journal of Urology
Chad M GridleyBodo E Knudsen

Abstract

Uric acid (UA) nephrolithiasis represents 10% of kidney stones in the US with low urine pH and high saturation of UA as the main risk factors for stone development. Dissolution therapy for UA kidney stones via urinary alkalization has been described as a treatment option. We present our experience in treating UA nephrolithiasis with medical dissolution therapy. A retrospective review was performed of UA stone patients referred for surgery but treated with dissolution therapy between July 2007 and July 2016. Patients were identified using ICD-9 codes. Patients were treated with potassium citrate alone or in combination with allopurinol. Serial imaging and urine pH were obtained at follow-up. Demographics, aggregate stone size, time to stone clearance, urine pH (office dip), and complications were recorded. Twenty-four patients (14 men and 10 women) were identified that started medical dissolution therapy for UA nephrolithiasis after initial referral for surgical management. Three patients (13%) did not tolerate the initiation of dissolution therapy and discontinued this treatment. Of the 21 patients that were maintained on dissolution therapy, 14 patients (67%) showed complete resolution of nephrolithiasis and 7 patients (33%) s...Continue Reading

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Citations

May 14, 2020·Current Opinion in Nephrology and Hypertension·Triet Vincent M Tran, Naim M Maalouf
Dec 8, 2019·World Journal of Urology·Senol Tonyali
Dec 18, 2020·Current Opinion in Urology·Lazaros TzelvesAndreas Skolarikos
Jun 26, 2021·Journal of Nephrology·Jonathan MooreMitchell Humphreys

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