Medical epidemiology of patients surviving ten years after liver transplantation

Clinical Transplantation
Kerri A SimoDavid A Gerber

Abstract

The transition into extended long-term follow-up after liver transplantation raises a new series of issues with respect to continuing care of this population. A retrospective study was performed, analyzing patients who underwent orthotopic liver transplant (OLT) and survived ≥10 yr at a single institution. Long-term comorbidities such as diabetes mellitus (DM), hypertension (HTN), chronic kidney disease (CKD), coronary artery disease (CAD), and obesity were identified and standardized prevalence ratios ([SPR]) utilized to compare with the general US population. There was an increased prevalence of HTN ([SPR] = 2.25 ± 0.61), DM ([SPR] = 2.67 ± 0.72), and CKD ([SPR] = 15.3 ± 4.04) but not CAD or obesity. In multivariate analysis, non-viral etiology of end-stage liver disease was associated with CKD (OR 3.42 CI 1.11-10.53), and an initial glomerular filtration rate (GFR) <60 mL/min per 1.73 m(2) (CKD stages III-V) was associated with HTN (OR 4.62 CI 1.14-18.73) after OLT. Creatinine ≥ 1.5 mg/dL at 10 yr was associated with an initial GFR <60 mL/min per 1.73 m(2) (p = 0.000) and CAD after OLT (p = 0.012). Patients, 10 yr after OLT, have a significantly higher prevalence of HTN, DM, and CKD than the general population, which is not ...Continue Reading

References

Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Jun 14, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·M Isabel T D CorreiaAgnaldo Soares Lima
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Apr 9, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Evangeline PilleboutDenis Glotz
May 15, 2007·Transplantation·George Mells, James Neuberger
Jun 5, 2007·Clinics in Liver Disease·Janus P Ong, Zobair M Younossi
Jul 1, 2008·Transplantation Proceedings·G de BoccardoE Akalin

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Citations

Aug 21, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kymberly D Watt
Feb 13, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Lucilene R AnastácioEduardo G Vilela
Nov 23, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Lynn A FussnerKymberly D Watt
Jun 9, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·UNKNOWN Women in Hepatology Group, UNKNOWN Italian Association for the Study of the Liver (AISF)
Mar 31, 2019·Clinical Transplantation·Sarah R LieberA Sidney Barritt
Feb 28, 2014·Revista do Colégio Brasileiro de Cirurgiões·Lucilene Rezende AnastácioMaria Isabel T D Correia

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