Medical-Grade Honey for the Treatment of Extravasation-Induced Injuries in Preterm Neonates: A Case Series.

Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses
Eleftherios Smaropoulos, Niels A J Cremers

Abstract

Preterm neonates often depend on peripheral intravenous administration of nutrition and medication. Since their skin is not fully developed and very vulnerable, extravasation injury is a risk. Medical-grade honey (MGH) possesses antimicrobial activity and stimulates wound healing; although its use in neonatal patients is limited. We present a case series of 7 preterm neonates (28-36 weeks of gestation) with extravasation injuries secondary to peripheral intravenous administration of total parental nutrition and medication. Extravasation injury following the unintentional leakage of total parenteral nutrition, and medication into the surrounding tissue. Signs of extravasation include local pain, erythema, burning, pruritus, and/or swelling. All extravasation injuries were treated with daily cleaning and application of MGH. Some of the cases needed additional surgical intervention or assisted debridement. After treatment, all extravasation injury wounds presented with granulation tissue formation progressed to normal epithelialization and closed in 7 to 67 days (median: 32 days). Upon initial application, peripheral edema and inflammation decreased. When present, necrotic tissue was effectively debrided, slough was removed, and n...Continue Reading

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Citations

Jan 17, 2021·Journal of Fungi·Theun de GrootJacques F Meis
May 11, 2021·Frontiers in Pharmacology·Carlos Martinez-ArmentaAlberto López-Reyes
Sep 3, 2021·Veterinary and Animal Science·Hendrik J MaraisNiels A J Cremers

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